ArticleEuropean radiology2019
Dual-energy CT in early acute pancreatitis: improved detection using iodine quantification.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 56 citations in OpenAlex.
- What you don't see matters: dual-energy CT in emergency radiology.Japanese journal of radiology · 2026Review
- Pancreatic extracellular volume fraction based on dual-energy computed tomography iodine maps: association with diabetes.Quantitative imaging in medicine and surgery · 2025Article
- Impact of patient habitus and acquisition protocol on iodine quantification in dual-source photon-counting computed tomography.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Evaluation of pancreatic iodine uptake and related influential factors in multiphase dual-energy CT.European radiology · 2024Article
- Dual-energy CT late arterial phase iodine maps for the diagnosis of acute non-occlusive mesenteric ischemia.La Radiologia medica · 2024Article
- Standardization of Dual-Energy CT Iodine Uptake of the Abdomen and Pelvis: Defining Reference Values in a Big Data Cohort.Diagnostics (Basel, Switzerland) · 2024Article
- Optimization of window settings for coronary arteries assessment using spectral CT-derived virtual monoenergetic imaging.La Radiologia medica · 2024Article
- Pancreatic Iodine Density and Fat Fraction on Dual-Energy Computed Tomography in Acute Pancreatitis.Diagnostics (Basel, Switzerland) · 2024Article
- Dual-Energy CT Iodine Uptake of Head and Neck: Definition of Reference Values in a Big Data Cohort.Diagnostics (Basel, Switzerland) · 2024Article
- Dual-Energy CT Material Decomposition: The Value in the Detection of Lymph Node Metastasis from Breast Cancer.Diagnostics (Basel, Switzerland) · 2024Article
- Differentiation of Hamartomas and Malignant Lung Tumors in Single-Phased Dual-Energy Computed Tomography.Tomography (Ann Arbor, Mich.) · 2024Article
- Complementary comments on diagnosis, severity and prognosis prediction of acute pancreatitis.World journal of gastroenterology · 2024Article
- Radiomics analysis of pancreas based on dual-energy computed tomography for the detection of type 2 diabetes mellitus.Frontiers in medicine · 2024Article
- Quantifying iodine concentration in the normal bowel wall using dual-energy CT: influence of patient and contrast characteristics.Scientific reports · 2023Article
- [Current CT developments in imaging of pancreatic diseases].Radiologie (Heidelberg, Germany) · 2023Review
- Differential diagnosis of adrenal adenomas and metastases using spectral parameters in dual-layer detector spectral CT.Journal of cancer research and clinical oncology · 2023Article
- Improved Coronary Artery Visualization Using Virtual Monoenergetic Imaging from Dual-Layer Spectral Detector CT Angiography.Diagnostics (Basel, Switzerland) · 2023Article
- Feasibility of using software-aided selection of virtual monoenergetic level for optimal image quality of acute necrotising pancreatitis based on dual-energy computed tomography: a preliminary study.BMC medical imaging · 2023Article
- Virtual Monoenergetic Imaging of Lower Extremities Using Dual-Energy CT Angiography in Patients with Diabetes Mellitus.Diagnostics (Basel, Switzerland) · 2023Article
- Multi-Contrast Differentiation by Dual-Energy Spectral CT Angiography in a Patient with Pulmonary Barium Granulomas.Diagnostics (Basel, Switzerland) · 2023Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the diagnostic performance of a dual-energy computed tomography (DECT)-based technique using iodine quantification and fat fraction analysis for the diagnosis of early acute pancreatitis
methodsIn this retrospective study, 45 patients (35 men and 10 women; mean age, 54.9 ± 14.0 years) with early acute pancreatitis were included. Serum lipase levels and follow-up examinations served as the reference standard. A matched control group (n = 45) was assembled for evaluation of material decomposition values of normal pancreatic parenchyma. Three blinded radiologists independently interpreted all cases on conventional grayscale DECT series. In addition, readers re-evaluated all cases by manually performing region-of-interest (ROI) measurements on pancreatic-phase DECT material density images of the head, body, and tail of each patient's pancreas. Receiver operating characteristic (ROC) curve analysis was performed to estimate the optimal threshold for discriminating between inflammatory and normal pancreas parenchyma.
resultsDECT-based iodine density values showed significant differences between inflammatory (1.8 ± 0.3 mg/mL) and normal pancreatic parenchyma (2.7 ± 0.7 mg/mL) (p ≤ 0.01). Fat fraction measurements showed no significant differences (p = 0.08). The optimal iodine density threshold for the diagnosis of acute pancreatitis was 2.1 mg/mL with a sensitivity of 96% and specificity of 77%. Iodine quantification revealed an area under the curve (AUC) of 0.86, significantly higher compared to standard image evaluation of the radiologists (AUC, 0.80; sensitivity, 78%; specificity, 82%) (p < 0.01).
conclusionDECT using iodine quantification allows for diagnosis of early acute pancreatitis with higher sensitivity compared to standard image evaluation. KEY POINTS: • Iodine density values showed significant differences between inflammatory and normal pancreatic parenchyma. • DECT using iodine quantification allows for diagnosis of early acute pancreatitis. • An iodine density of ≤ 2.1 mg/mL optimizes the diagnosis of acute pancreatitis.
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