Evidence map›Paper›PMID 30488108›Full record

ArticleEuropean radiology2019

Magnitude dependent discordance in liver stiffness measurements using elastography point quantification with transient elastography as the reference test.

Ivica Grgurevic, Nermin Salkic, Tonci Bozin, Sanda Mustapic, Vladimir Matic, Ivo Dumic-Cule, Ida Tjesic Drinkovic, Tomislav Bokun

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Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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5 citing papers in PubMed.

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5 · Who and what money

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8 authors.

Ivica GrgurevicDepartment of Gastroenterology, Hepatology and Clinical Nutrition; Department of Medicine, University Hospital Dubrava, University of Zagreb School of Medicine and Faculty of Pharmacy and Biochemistry, Avenija Gojka Suska 6, 10000, Zagreb, Croatia. ivica.grgurevic@zg.htnet.hr.ORCID http://orcid.org/0000-0003-0520-3483
Nermin SalkicDepartment of Gastroenterology and Hepatology, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.
Tonci BozinDepartment of Gastroenterology, Hepatology and Clinical Nutrition; Department of Medicine, University Hospital Dubrava, University of Zagreb School of Medicine and Faculty of Pharmacy and Biochemistry, Avenija Gojka Suska 6, 10000, Zagreb, Croatia.
Sanda MustapicDepartment of Gastroenterology, Hepatology and Clinical Nutrition; Department of Medicine, University Hospital Dubrava, University of Zagreb School of Medicine and Faculty of Pharmacy and Biochemistry, Avenija Gojka Suska 6, 10000, Zagreb, Croatia.
Vladimir MaticDepartment of Gastroenterology, Hepatology and Clinical Nutrition; Department of Medicine, University Hospital Dubrava, University of Zagreb School of Medicine and Faculty of Pharmacy and Biochemistry, Avenija Gojka Suska 6, 10000, Zagreb, Croatia.
Ivo Dumic-CuleDepartment of Diagnostic and Interventional Radiology, University Hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Croatia.
Ida Tjesic DrinkovicDepartment of Gastroenterology, Hepatology and Clinical Nutrition; Department of Medicine, University Hospital Dubrava, University of Zagreb School of Medicine and Faculty of Pharmacy and Biochemistry, Avenija Gojka Suska 6, 10000, Zagreb, Croatia.
Tomislav BokunDepartment of Gastroenterology, Hepatology and Clinical Nutrition; Department of Medicine, University Hospital Dubrava, University of Zagreb School of Medicine and Faculty of Pharmacy and Biochemistry, Avenija Gojka Suska 6, 10000, Zagreb, Croatia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate diagnostic performance of point shear wave elastography by elastography point quantification (ElastPQ) for non-invasive assessment of liver fibrosis in patients with chronic liver diseases (CLD).

methodsLiver stiffness measurement (LSM) by transient elastography (TE) and ElastPQ was performed in patients with CLD and healthy volunteers. The stage of liver fibrosis was defined by TE which served as the reference. We compared two methods by using correlation, area under the receiver operating characteristics curve (AUC) analysis, Bland and Altman plot and Passing-Bablok regression.

resultsA total of 185 subjects (20 healthy volunteers and 165 patients with CLD (128 non-alcoholic fatty liver disease), 83 (44.9%) females, median age 53 years, BMI 27.3 kg/m

conclusionElastPQ is reliable method for assessment of liver fibrosis but LSM values are not interchangeable with TE, especially above 10 kPa. Diagnostic performance of ElastPQ for sub-classification of patients with compensated advanced chronic liver disease should therefore be furtherly investigated. KEY POINTS: • ElastPQ appears to be reliable method for assessment of liver fibrosis, with data presented here mostly applicable to NAFLD. • LSM values produced by TE and ElastPQ are NOT interchangeable-in values < 10 kPa, they are similar, but in values > 10 kPa, they appear to be increasingly and significantly different. • Diagnostic performance of ElastPQ for sub-classification of patients with compensated advanced chronic liver disease should be furtherly investigated.

Indexed as

AdolescentAdultAgedAged, 80 and overCross-Sectional StudiesElasticityElasticity Imaging TechniquesFemaleHumansLiverLiver DiseasesMaleMiddle AgedReference ValuesReproducibility of ResultsROC CurveDiagnostic performanceLiver fibrosisLiver stiffness measurementNon-alcoholic fatty liver disease

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.