ArticleEuropean radiology2019
Aortic stiffness in aortic stenosis assessed by cardiovascular MRI: a comparison between bicuspid and tricuspid valves.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Assessment of Potential Predictors of Aortic Stenosis Severity Using ECG-Gated Multidetector CT in Patients with Bicuspid and Tricuspid Aortic Valves Prior to TAVI.Journal of clinical medicine · 2026Article
- Resource efficient aortic distensibility calculation by end to end spatiotemporal learning of aortic lumen from multicentre multivendor multidisease CMR images.Scientific reports · 2023Article
- Feasibility of Wave Intensity Analysis from 4D Cardiovascular Magnetic Resonance Imaging Data.Bioengineering (Basel, Switzerland) · 2023Article
- PHACTR1 modulates vascular compliance but not endothelial function: a translational study.Cardiovascular research · 2023Article
- Aortic wall shear stress in bicuspid aortic valve disease-10-year follow-up.Cardiovascular diagnosis and therapy · 2023Article
- Global Aortic Pulse Wave Velocity is Unchanged in Bicuspid Aortopathy With Normal Valve Function but Elevated in Patients With Aortic Valve Stenosis: Insights From a 4D Flow MRI Study of 597 Subjects.Journal of magnetic resonance imaging : JMRI · 2023Article
- The role of 4-dimensional flow in the assessment of bicuspid aortic valve and its valvulo-aortopathies.The British journal of radiology · 2022Review
- Clinical implications of the biomechanics of bicuspid aortic valve and bicuspid aortopathy.Frontiers in cardiovascular medicine · 2022Review
- Arterial Stiffness in Aortic Stenosis.Arquivos brasileiros de cardiologia · 2021Article
- Evaluation of Plaque Characteristics and Inflammation Using Magnetic Resonance Imaging.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
objectivesTo compare aortic size and stiffness parameters on MRI between bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV) patients with aortic stenosis (AS).
methodsMRI was performed in 174 patients with asymptomatic moderate-severe AS (mean AVAI 0.57 ± 0.14 cm
resultsThe AA and DA areas were lower in the controls, with no difference in DA distensibility or PWV, but slightly lower AA distensibility than in the patient group. With increasing age, there was a decrease in distensibility and an increase in PWV. After correcting for age, the AA maximum cross-sectional area was higher in bicuspid vs. tricuspid patients (12.97 [11.10, 15.59] vs. 10.06 [8.57, 12.04] cm
conclusionsIn patients with significant AS, BAV patients do not have increased aortic stiffness compared to those with TAV despite increased ascending aortic dimensions. Those with type-II BAV have less aortic stiffness despite greater dimensions. These results demonstrate a dissociation between aortic dilatation and stiffness and suggest that altered flow patterns may play a role. KEY POINTS: • Both cellular abnormalities secondary to genetic differences and abnormal flow patterns have been implicated in the pathophysiology of aortic dilatation and increased vascular complications associated with bicuspid aortic valves (BAV). • We demonstrate an increased ascending aortic size in patients with BAV and moderate to severe AS compared to TAV and controls, but no difference in aortic stiffness parameters, therefore suggesting a dissociation between dilatation and stiffness. • Sub-group analysis showed greater aortic size but lower stiffness parameters in those with BAV type-II AS compared to BAV type-I.
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