Evidence map›Paper›PMID 30487790›Full record

ArticleFrontiers in immunology2018

Major TCR Repertoire Perturbation by Immunodominant HLA-B

Meriem Attaf, Amna Malik, Mai C Severinsen, Julia Roider, Paul Ogongo, Søren Buus, Thumbi Ndung'u, Alasdair Leslie, Henrik N Kløverpris, Philippa C Matthews and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 5 countries.

Meriem AttafDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.
Amna MalikDepartment of Paediatrics, University of Oxford, Oxford, United Kingdom.
Mai C SeverinsenAfrica Health Research Institute, Durban, South Africa.
Julia RoiderAfrica Health Research Institute, Durban, South Africa.
Paul OgongoAfrica Health Research Institute, Durban, South Africa.
Søren BuusLaboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Thumbi Ndung'uAfrica Health Research Institute, Durban, South Africa.
Alasdair LeslieAfrica Health Research Institute, Durban, South Africa.
Henrik N KløverprisAfrica Health Research Institute, Durban, South Africa.
Philippa C MatthewsNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Andrew K SewellDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.
Philip GoulderDepartment of Paediatrics, University of Oxford, Oxford, United Kingdom.
Africa Health Research Institute · ZAUniversity of Oxford · GBCardiff University · GBUniversity of Copenhagen · DKLudwig-Maximilians-Universität München · DEUniversity College London · GB

Funding

Maximising Cure Potential in Paediatric HIV InfectionR01AI133673 · NIAID · UNIVERSITY OF OXFORD · PI GOULDER, PHILIP J · 2017 to 2021
$1.4M
NIAID NIH HHS R01 AI133673Wellcome TrustWellcome Trust WT104748MA
6 · The paper itself

Abstract

Lack of disease during chronic human cytomegalovirus (CMV) infection depends on the maintenance of a high-frequency CMV-specific T cell response. The composition of the T cell receptor (TCR) repertoire underlying this response remains poorly characterised, especially within African populations in which CMV is endemic from infancy. Here we focus on the immunodominant CD8+ T cell response to the immediate-early 2 (IE-2)-derived epitope NEGVKAAW (NW8) restricted by HLA-B

Indexed as

Black PeopleAdultCD8-Positive T-LymphocytesCytomegalovirusCytomegalovirus InfectionsEpitopes, T-LymphocyteFlow CytometryHigh-Throughput Nucleotide SequencingHLA-B44 AntigenHumansImmediate-Early ProteinsImmunity, CellularImmunodominant EpitopesMalePeptidesReceptors, Antigen, T-CellEpitopes, T-LymphocyteHLA-B*44:03 antigenHLA-B44 AntigenIE2 protein, CytomegalovirusImmediate-Early ProteinsImmunodominant EpitopesPeptidesReceptors, Antigen, T-CellTrans-ActivatorscytomegalovirusHLA-B*44:03repertoiresequencingT cellT cell receptor

Identifiers

PMID30487790
PMCPMC6246681
OpenAlexW2901814071

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.