Evidence map›Paper›PMID 30487786›Full record

ArticleFrontiers in microbiology2018

Microbial Biomarkers of Intestinal Barrier Maturation in Preterm Infants.

Bing Ma, Elias McComb, Pawel Gajer, Hongqiu Yang, Mike Humphrys, Adora C Okogbule-Wonodi, Alessio Fasano, Jacques Ravel, Rose M Viscardi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 63 citations in OpenAlex.

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  14. Malnutrition, poor post-natal growth, intestinal dysbiosis and the developing lung.Journal of perinatology : official journal of the California Perinatal Association · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Bing MaInstitute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States.
Elias McCombInstitute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States.
Pawel GajerInstitute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States.
Hongqiu YangInstitute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States.
Mike HumphrysInstitute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States.
Adora C Okogbule-WonodiDepartment of Pediatrics and Child Health, Howard University College of Medicine, Washington, DC, United States.
Alessio FasanoDepartment of Pediatrics, Basic, Clinical and Translational Research, MassGeneral Hospital for Children, Boston, MA, United States.
Jacques RavelInstitute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States.
Rose M ViscardiDepartment of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, United States.
University of Maryland, Baltimore · USHoward University · USMaineGeneral Medical Center · US

Funding

Effect of Lactobacillus GG on gut permeability and microbiome in VLBW neonatesR34AT006945 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI FASANO, ALESSIO, VISCARDI, ROSE MARIE · 2011 to 2013
$679k
NCCIH NIH HHS R34 AT006945
6 · The paper itself

Abstract

Intestinal barrier immaturity, or "leaky gut," is the proximate cause of susceptibility to necrotizing enterocolitis in preterm neonates. However, the impact of intestinal microbiota development on intestinal mucosal barrier maturation has not been evaluated in this population. In this study, we investigated a longitudinally sampled cohort of 38 preterm infants < 33 weeks gestation monitored for intestinal permeability (IP) and fecal microbiota during the first 2 weeks of life. Rapid decrease in IP indicating intestinal barrier function maturation correlated with significant increase in community diversity. In particular, members of the Clostridiales and

Indexed as

Bifidobacteriumbreastmilk feedingClostridialesintestinal microbiotaintestinal permeabilityleaky gutnecrotizing enterocolitispreterm infant

Identifiers

PMID30487786
PMCPMC6246636
OpenAlexW2951080421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.