Evidence map›Paper›PMID 30487776›Full record

ArticleFrontiers in neurology2018

Silencing of Hypoglossal Motoneurons Leads to Sleep Disordered Breathing in Lean Mice.

Thomaz A Fleury Curado, Huy Pho, Olga Dergacheva, Slava Berger, Rachel Lee, Carla Freire, Aya Asherov, Luis U Sennes, David Mendelowitz, Alan R Schwartz and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

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  10. Intranasal Leptin Prevents Opioid-induced Sleep-disordered Breathing in Obese Mice.American journal of respiratory cell and molecular biology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Thomaz A Fleury CuradoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Huy PhoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Olga DergachevaDepartment of Pharmacology and Physiology, The George Washington University, Washington, DC, United States.
Slava BergerDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Rachel LeeDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Carla FreireDepartment of Otolaryngology, University of Sao Paulo, São Paulo, Brazil.
Aya AsherovDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Luis U SennesDepartment of Otolaryngology, University of Sao Paulo, São Paulo, Brazil.
David MendelowitzDepartment of Pharmacology and Physiology, The George Washington University, Washington, DC, United States.
Alan R SchwartzDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Vsevolod Y PolotskyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Johns Hopkins Medicine · USJohns Hopkins University · USGeorge Washington University · USUniversidade de São Paulo · BR

Funding

Melanocortin 4 signaling in the carotid body in obesityR01HL133100 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Vsevolod Y Polotsky, Wan-yee Tang · 2016 to 2026
$7.1M
Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2016 to 2020
$5.9M
Treatment of Sleep Apnea by Targeting Leptin SignalingR01HL128970 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MENDELOWITZ, DAVID, POLOTSKY, VSEVOLOD Y · 2015 to 2023
$5.4M
Chemogenetic approach to treat Obstructive Sleep ApneaR01HL138932 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POLOTSKY, VSEVOLOD Y · 2017 to 2020
$2.4M
NHLBI NIH HHS R01 HL128970NHLBI NIH HHS R01 HL138932
6 · The paper itself

Abstract

Obstructive Sleep Apnea (OSA) is a prevalent condition and a major cause of morbidity and mortality in Western Society. The loss of motor input to the tongue and specifically to the genioglossus muscle during sleep is associated with pharyngeal collapsibility and the development of OSA. We applied a novel chemogenetic method to develop a mouse model of sleep disordered breathing Our goal was to reversibly silence neuromotor input to the genioglossal muscle using an adeno-associated viral vector carrying inhibitory designer receptors exclusively activated by designer drugs AAV5-hM4Di-mCherry (DREADD), which was delivered bilaterally to the hypoglossal nucleus in fifteen C57BL/6J mice. In the

Indexed as

chemogeneticneuromuscular activityobstructive sleeep apneasleepupper airway

Identifiers

PMID30487776
PMCPMC6246694
OpenAlexW2901149043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.