ArticleFrontiers in physiology2018
Are the Cognitive Alterations Present in Children Born From Preeclamptic Pregnancies the Result of Impaired Angiogenesis? Focus on the Potential Role of the VEGF Family.
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Association between prenatal exposure to antihypertensive medication and neurodevelopmental and educational outcomes in children.Scientific reports · 2025Article
- Brain and brain blood vessels histological description in autopsies of fetuses/neonates born to mothers with hypertension during pregnancy. A case-control study.Lancet regional health. Americas · 2025Article
- sFlt-1 impairs neurite growth and neuronal differentiation in SH-SY5Y cells and human neurons.Bioscience reports · 2024Article
- Reduced Brain Cortex Angiogenesis in the Offspring of the Preeclampsia-Like Syndrome.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Language Impairment in Children of Mothers with Gestational Diabetes, Preeclampsia, and Preterm Delivery: Current Hypothesis and Potential Underlying Mechanisms : Language Impartment and Pregnancy Complications.Advances in experimental medicine and biology · 2023Article
- Abnormal cerebral microvascular perfusion and reactivity in female offspring of reduced uterine perfusion pressure (RUPP) mice model.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Antioxidants Attenuate Heat Shock Induced Premature Senescence of Bovine Mesenchymal Stem Cells.International journal of molecular sciences · 2022Article
- Association of Preeclampsia and Perinatal Complications With Offspring Neurodevelopmental and Psychiatric Disorders.JAMA network open · 2022Article
- Systemic Maternal Human sFLT1 Overexpression Leads to an Impaired Foetal Brain Development of Growth-Restricted Foetuses upon Experimental Preeclampsia.Oxidative medicine and cellular longevity · 2022Article
- Male HELLP pups experience sensorimotor delays and reduced body weight.Physiology & behavior · 2021Article
- Neurologic Sequelae Associated with Hypertensive Disorders of Pregnancy.Children (Basel, Switzerland) · 2021Review
- Prenatal intake of omega-3 promotes Wnt/β-catenin signaling pathway, and preserves integrity of the blood-brain barrier in preeclamptic rats.Physiological reports · 2021Article
- Development of the Neuro-Immune-Vascular Plexus in the Ventricular Zone of the Prenatal Rat Neocortex.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Early Abnormal Placentation and Evidence of Vascular Endothelial Growth Factor System Dysregulation at the Feto-Maternal Interface After Periconceptional Alcohol Consumption.Frontiers in physiology · 2021Review
- Pre-eclampsia Complicated With Maternal Renal Dysfunction Is Associated With Poor Neurological Development at 3 Years Old in Children Born Before 34 Weeks of Gestation.Frontiers in pediatrics · 2021Article
- Hypertensive disorders in pregnancy and child development at 36 months in the All Our Families prospective cohort study.PloS one · 2021Article
- Association of Preeclampsia in Term Births With Neurodevelopmental Disorders in Offspring.JAMA psychiatry · 2020Article
- Traffic-related particulate matter affects behavior, inflammation, and neural integrity in a developmental rodent model.Environmental research · 2020Article
- Promoter methylation changes and vascular dysfunction in pre-eclamptic umbilical vein.Clinical epigenetics · 2019Article
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Authors and funding
6 authors.
Funding
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Abstract
Evidence from clinical studies has proposed that children born from preeclamptic women have a higher risk of suffering neurological, psychological, or behavioral alterations. However, to date, the mechanisms behind these outcomes are poorly understood. Here, we speculate that the neurodevelopmental alterations in the children of preeclamptic pregnancies result from impaired angiogenesis. The pro-angiogenic factors vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) are key regulators of both vascular and neurological development, and it has been widely demonstrated that umbilical blood of preeclamptic pregnancies contains high levels of soluble VEGF receptor type 1 (sFlt-1), a decoy receptor of VEGF. As a consequence, this anti-angiogenic state could lead to long-lasting neurological outcomes. In this non-systematic review, we propose that alterations in the circulating concentrations of VEGF, PlGF, and sFlt-1 in preeclamptic pregnancies will affect both fetal cerebrovascular function and neurodevelopment, which in turn may cause cognitive alterations in post-natal life.
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