Evidence map›Paper›PMID 30487745›Full record

ArticleFrontiers in aging neuroscience2018

Multiplex Networks for Early Diagnosis of Alzheimer's Disease.

Nicola Amoroso, Marianna La Rocca, Stefania Bruno, Tommaso Maggipinto, Alfonso Monaco, Roberto Bellotti, Sabina Tangaro

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  17. Unsuspected Involvement of Spinal Cord in Alzheimer Disease.Frontiers in cellular neuroscience · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicola AmorosoDipartimento Interateneo di Fisica "M. Merlin", Università degli studi di Bari "A. Moro", Bari, Italy.
Marianna La RoccaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Stefania BrunoBlackheath Brain Injury Rehabilitation Centre, London, United Kingdom.
Tommaso MaggipintoDipartimento Interateneo di Fisica "M. Merlin", Università degli studi di Bari "A. Moro", Bari, Italy.
Alfonso MonacoDipartimento Interateneo di Fisica "M. Merlin", Istituto Nazionale di Fisica Nucleare, Sezione di Bari, Bari, Italy.
Roberto BellottiDipartimento Interateneo di Fisica "M. Merlin", Università degli studi di Bari "A. Moro", Bari, Italy.
Sabina TangaroDipartimento Interateneo di Fisica "M. Merlin", Istituto Nazionale di Fisica Nucleare, Sezione di Bari, Bari, Italy.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Analysis and quantification of brain structural changes, using Magnetic Resonance Imaging (MRI), are increasingly used to define novel biomarkers of brain pathologies, such as Alzheimer's disease (AD). Several studies have suggested that brain topological organization can reveal early signs of AD. Here, we propose a novel brain model which captures both intra- and inter-subject information within a multiplex network approach. This model localizes brain atrophy effects and summarizes them with a diagnostic score. On an independent test set, our multiplex-based score segregates (i) normal controls (NC) from AD patients with a 0.86±0.01 accuracy and (ii) NC from mild cognitive impairment (MCI) subjects that will convert to AD (cMCI) with an accuracy of 0.84±0.01. The model shows that illness effects are maximally detected by parceling the brain in equal volumes of 3, 000 mm

Indexed as

Alzheimer's diseasebrain Connectivitydiagnosis support systemmachine learningmagnetic resonance imaging (MRI)mild cognitive impairmentmultiplex networks

Identifiers

PMID30487745
PMCPMC6247675

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.