ArticleWorld journal of gastroenterology2018
Biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke.
Article in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Pooled it
- Clinical features and prognosis of patients with malignant tumors complicated by cerebral infarction.American journal of cancer research · 2026Article
- Atrial fibrillation and ischemic stroke in cancer: the latest scientific evidence, current management, and future directions.Journal of thrombosis and thrombolysis · 2025Review
- Crosstalk Between the Nervous System and Colorectal Cancer.Neuroscience bulletin · 2025Review
- CombiningBiomedical reports · 2024Article
- The investigation on the hypercoagulability of hepatocellular carcinoma-related cerebral infarction with thromboelastography.Brain and behavior · 2023Article
- The Index of Esophageal Cancer Related Ischemic Stroke: A Retrospective Patient Control Study.Neuropsychiatric disease and treatment · 2022Article
- Cellular Immune Signal Exchange From Ischemic Stroke to Intestinal Lesions Through Brain-Gut Axis.Frontiers in immunology · 2022Review
- Serum Alkaline Phosphatase in Cryptogenic Stroke Cases with Active Cancer.Internal medicine (Tokyo, Japan) · 2022Article
- Clinical practice: intravenous thrombolysis in a patient with active cancer who experienced wake-up stroke.The Journal of international medical research · 2021Article
- Independent risk factors and the potential predictors of bladder cancer-related ischemic stroke.The Journal of international medical research · 2020Article
- D-Dimer level was associated with prognosis in metastatic colorectal cancer: A Chinese patients based cohort study.Medicine · 2020Article
- Clinical Characteristics and Risk Factors of Lung Cancer-Associated Acute Ischemic Stroke.BioMed research international · 2019Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the specific biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke (CRCIS).
methodsA retrospective study was conducted on CRCIS patients (colorectal cancer patients with ischemic stroke without conventional stroke risk factors) registered at seven centers between January 2007 and December 2017. Clinical data and laboratory and imaging findings were compared with age- and sex- matched patients with colorectal cancer (CRC) without ischemic stroke that were admitted to the same hospital during the same period. Univariate and multivariate analyses were performed to analyze the independent risk factors for CRCIS. A receiver operator characteristic curve was configured to calculate the optimal cut-off value of the products of the independent risk factors for CRCIS.
resultsA total of 114 CRCIS patients and 114 CRC patients were included. Multiple lesions in multiple vascular territories were common in CRCIS patients (71, 62.28%). The levels of plasma D-dimer, carcinoembryonic antigen (CEA), cancer antigen 125, and neutrophil count were significantly higher in CRCIS patients than in CRC patients. Multiple logistic regression analysis revealed that plasma D-dimer levels [odds ratio (OR) = 1.002, 95% confidence interval (CI): 1.001-1.003,
conclusionHypercoagulability induced by elevated CEA and neutrophils may be an important cause of CRCIS. The CRCIS index, which serves as a biomarker of CRCIS, needs further study.
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