ArticleJournal of clinical biochemistry and nutrition2018
Simultaneous detection of reduced and oxidized forms of coenzyme Q10 in human cerebral spinal fluid as a potential marker of oxidative stress.
Article in Journal of clinical biochemistry and nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- CoQAntioxidants (Basel, Switzerland) · 2024Review
- Transferrin, insulin, and progesterone modulate intracellular concentrations of coenzyme Q and cholesterol, products of the mevalonate pathway, in undifferentiated PC12 cells.Journal of clinical biochemistry and nutrition · 2023Article
- Method for detecting CoQ10 incorporation in the mitochondrial respiratory chain supercomplex.Journal of clinical biochemistry and nutrition · 2023Article
- Cellular level of coenzyme Q increases with neuronal differentiation, playing an important role in neural elongations.Journal of clinical biochemistry and nutrition · 2022Article
- Reduced prosaposin levels in HepG2 cells with long-term coenzyme Q10 deficiency.Journal of clinical biochemistry and nutrition · 2022Article
- Coenzyme Q10 in the eye isomerizes by sunlight irradiation.Scientific reports · 2022Article
- Coenzyme Q10 levels increase with embryonic development in medaka.Journal of clinical biochemistry and nutrition · 2022Article
- Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
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Abstract
The redox balance of coenzyme Q10 in human plasma is a good marker of oxidative stress because the reduced form of coenzyme Q10 (ubiquinol-10) is very sensitive to oxidation and is quantitatively converted to its oxidized form (ubiquinone-10). Here we describe an HPLC method for simultaneous detection of ubiquinol-10 and ubiquinone-10 in human cerebral spinal fluid to meet a recent demand for measuring local oxidative stress. Since the levels of coenzyme Q10 in human cerebral spinal fluid are less than 1/500 of those in human plasma, cerebral spinal fluid extracted with 2-propanol requires concentration for electrochemical detection. Using human plasma diluted 500-fold with physiological saline as a pseudo-cerebral spinal fluid, we found that addition of
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