ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder.
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Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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54citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
What it found
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Epigenetic signatures relating to disease-associated genotypic burden in familial risk of bipolar disorder.Translational psychiatry · 2022Pooled it
- Change in circadian preference predicts sustained treatment outcomes in patients with unipolar depression and evening preference.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Trial
- Modulation of neuronal excitability and plasticity by BHLHE41 conveys lithium non-responsiveness.Molecular psychiatry · 2026Article
- Essential Information About Chronobiology and Chronotherapy for the Optimal Care of People With Bipolar Disorders: An Expert Consensus.Bipolar disorders · 2026Article
- Beyond composite scores in chronotype assessment: item-level predictive patterns in the Morningness-Eveningness Questionnaire.Scientific reports · 2026Observational
- Pathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients With Bipolar Disorder.Biological psychiatry global open science · 2025Article
- Circadian clock genes and cell survival in bipolar disorder: Insights into lithium responsiveness and molecular mechanisms in patient-derived neural progenitor cells and mouse neurons.The FEBS journal · 2025Article
- Beyond "Fire" and "Ashes": The Influence of Trait Characteristics on the Response to Mood Stabilizers in Bipolar Disorders.Brain sciences · 2025Article
- The Mechanisms of Lithium Action: The Old and New Findings.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Differential serum levels of CACNA1C, circadian rhythm and stress response molecules in subjects with bipolar disorder: Associations with genetic and clinical factors.Journal of affective disorders · 2024Article
- Co-morbid cannabis use disorder and chronotype are associated with mood symptom onset in people with bipolar disorder.Journal of psychiatric research · 2024Article
- Human iN neuronal model of schizophrenia displays dysregulation of chromogranin B and related neuropeptide transmitter signatures.Molecular psychiatry · 2024Article
- Differential contributions of circadian clock genes to cell survival in bipolar disorder patient derived neuronal progenitor cells distinguishes lithium responders and non-responders.Research square · 2024Article
- Differential Serum Levels of CACNA1C, Circadian Rhythm and Stress Response Molecules in Subjects with Bipolar Disorder: Associations with Genetic and Clinical Factors.medRxiv : the preprint server for health sciences · 2024Article
- Effectiveness of ultra-long-term lithium treatment: relevant factors and case series.International journal of bipolar disorders · 2024Review
- Possible Role of Correlation Coefficients and Network Analysis of Multiple Intracellular Proteins in Blood Cells of Patients with Bipolar Disorder in Studying the Mechanism of Lithium Responsiveness: A Proof-Concept Study.Journal of clinical medicine · 2024Article
- The sleep-circadian interface: A window into mental disorders.Proceedings of the National Academy of Sciences of the United States of America · 2024Review
- Review
- Significant contribution of chronotype to emotional well-being in chronic psychiatric outpatients in Greece.Neuroscience applied · 2024Article
- Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2023Article
Corrections and comments
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Authors and funding
62 authors at 19 institutions in 3 countries.
Michael J McCarthyDepartment of Psychiatry and Center for Circadian Biology, University of California, San Diego, 3350 La Jolla Village Dr. MC 116A, San Diego, CA, 92161, USA. mmccarthy@ucsd.edu.ORCID http://orcid.org/0000-0001-6219-4945
Heather WeiPsychiatry Service, VA San Diego Healthcare, San Diego, CA, 92161, USA.
Caroline M NievergeltDepartment of Psychiatry and Center for Circadian Biology, University of California, San Diego, 3350 La Jolla Village Dr. MC 116A, San Diego, CA, 92161, USA.ORCID http://orcid.org/0000-0001-5766-8923
Andrea StautlandDepartment of Clinical Medicine, Section for Psychiatry, University of Bergen, Bergen, Norway.
Adam X MaihoferDepartment of Psychiatry and Center for Circadian Biology, University of California, San Diego, 3350 La Jolla Village Dr. MC 116A, San Diego, CA, 92161, USA.ORCID http://orcid.org/0000-0003-4517-1623
David K WelshDepartment of Psychiatry and Center for Circadian Biology, University of California, San Diego, 3350 La Jolla Village Dr. MC 116A, San Diego, CA, 92161, USA.
Paul ShillingDepartment of Psychiatry and Center for Circadian Biology, University of California, San Diego, 3350 La Jolla Village Dr. MC 116A, San Diego, CA, 92161, USA.
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, Canada.
Ney Alliey-RodriguezDepartment of Psychiatry, University of Chicago, Chicago, USA.ORCID http://orcid.org/0000-0001-8594-5676
Amit AnandDepartment of Psychiatry, Indiana University, Bloomington, USA.
Ole A AndreassonJebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway.
Yokesh BalaramanDepartment of Psychiatry, Indiana University, Bloomington, USA.
Wade H BerrettiniDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Holli BertramDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Kristen J BrennandDepartments of Neuroscience and Psychiatry, Icahn School of Medicine at Mt Sinai, New York, USA.ORCID http://orcid.org/0000-0003-0993-5956
Joseph R CalabreseDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.
Cynthia V CalkinDepartment of Psychiatry, Dalhousie University, Halifax, Canada.
Ana ClaasenNeurogenomics Division, Translational Genomics Research Institute, Phoenix, USA.ORCID http://orcid.org/0000-0003-2069-2457
Clara ConroyDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.
William H CoryellDepartment of Psychiatry, University of Iowa, Iowa City, USA.
David W CraigNeurogenomics Division, Translational Genomics Research Institute, Phoenix, USA.
Nicole D'ArcangeloDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.
Anna DemodenaPsychiatry Service, VA San Diego Healthcare, San Diego, CA, 92161, USA.
Srdjan DjurovicJebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-8140-8061
Scott FeederDepartment of Psychiatry, The Mayo Clinic, Rochester, USA.
Carrie FisherDepartment of Psychiatry, Indiana University, Bloomington, USA.
Nicole FrazierDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Mark A FryeDepartment of Psychiatry, The Mayo Clinic, Rochester, USA.
Fred H GageLaboratory of Genetics, Salk Institute for Biological Studies, La Jolla, USA.ORCID http://orcid.org/0000-0002-0938-4106
Keming GaoDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.
Julie GarnhamDepartment of Psychiatry, Dalhousie University, Halifax, Canada.
Elliot S GershonDepartment of Psychiatry, University of Chicago, Chicago, USA.ORCID http://orcid.org/0000-0003-4818-8631
Kara GlazerDepartment of Psychiatry, Johns Hopkins University, Baltimore, USA.
Fernando GoesDepartment of Psychiatry, Johns Hopkins University, Baltimore, USA.
Toyomi GotoDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.
Gloria HarringtonDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Petter JakobsenNorment and KG Jebsen Centre for Neuropsychiatry, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Masoud KamaliDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Elizabeth KarbergDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.
Marisa KellyDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-7151-1938
Susan G LeckbandPsychiatry Service, VA San Diego Healthcare, San Diego, CA, 92161, USA.
Falk LohoffDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Melvin G McInnisDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-0375-6247
Francis MondimoreDepartment of Psychiatry, Johns Hopkins University, Baltimore, USA.
Gunnar MorkenDivision of Psychiatry, St. Olav University Hospital of Trondheim and Department of Mental Health Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0003-1972-5901
John I NurnbergerDepartment of Psychiatry, Indiana University, Bloomington, USA.
Sarah ObralDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.
Ketil J OedegaardDepartment of Clinical Medicine, Section for Psychiatry, University of Bergen, Bergen, Norway.
Abigail OrtizDepartment of Psychiatry, University of Ottawa, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0001-6886-767X
Megan RitcheyDepartment of Psychiatry, Johns Hopkins University, Baltimore, USA.
Kelly RyanDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Martha SchinagleDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.
Helle SchoeyenDepartment of Clinical Medicine, Section for Psychiatry, University of Bergen, Bergen, Norway.
Candice SchwebelDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Martha ShawDepartment of Psychiatry, University of Chicago, Chicago, USA.
Tatyana ShekhtmanDepartment of Psychiatry and Center for Circadian Biology, University of California, San Diego, 3350 La Jolla Village Dr. MC 116A, San Diego, CA, 92161, USA.
Claire SlaneyDepartment of Psychiatry, Dalhousie University, Halifax, Canada.
Emma StappDepartment of Psychiatry, Johns Hopkins University, Baltimore, USA.ORCID http://orcid.org/0000-0003-0628-0704
Szabolcs SzelingerNeurogenomics Division, Translational Genomics Research Institute, Phoenix, USA.
Bruce TarwaterNeurogenomics Division, Translational Genomics Research Institute, Phoenix, USA.
Peter P ZandiDepartment of Psychiatry, Johns Hopkins University, Baltimore, USA.
John R KelsoeDepartment of Psychiatry and Center for Circadian Biology, University of California, San Diego, 3350 La Jolla Village Dr. MC 116A, San Diego, CA, 92161, USA.
Case Western Reserve University · USUniversity of California San Diego · USUniversity of Michigan · USJohns Hopkins University · USDalhousie University · CAIndiana University Bloomington · USTranslational Genomics Research Institute · USUniversity of Chicago · USUniversity of Pennsylvania · USVA San Diego Healthcare System · USHaukeland University Hospital · NOMayo Clinic · USUniversity of Bergen · NOUniversity of Oslo · NOIcahn School of Medicine at Mount Sinai · USNorwegian University of Science and Technology · NOSalk Institute for Biological Studies · USUniversity of Iowa · USUniversity of Ottawa · CA
Funding
Clinical Genomics and Experimental TherapeuticsZIAAA000242 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI LOHOFF, FALK · 2015 to 2025
$26.7MPharmacogenomics of Mood Stabilizer Response in Bipolar DisorderU01MH092758 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 2010 to 2014
$6.2MCellular Circadian Clocks in Mood DisordersI01BX001146 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI WELSH, DAVID K · 2012 to 2020
–Circadian Rhythms in Neuronal Models of Bipolar DisorderI01BX003431 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI MCCARTHY, MICHAEL JOSEPH · 2017 to 2025
–BLRD VA I01 BX001146BLRD VA I01 BX003431NIMH NIH HHS U01 MH092758U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH92758U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) U01MH092758
Abstract
Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an effective mood stabilizer treatment for BD, but only a minority of patients fully respond to monotherapy. Presently, we hypothesized that lithium-responsive BD patients (Li-R) would show characteristic differences in chronotype and cellular circadian rhythms compared to lithium non-responders (Li-NR). Selecting patients from a prospective, multi-center, clinical trial of lithium monotherapy, we examined morning vs. evening preference (chronotype) as a dimension of circadian rhythm function in 193 Li-R and Li-NR BD patients. From a subset of 59 patient donors, we measured circadian rhythms in skin fibroblasts longitudinally over 5 days using a bioluminescent reporter (Per2-luc). We then estimated circadian rhythm parameters (amplitude, period, phase) and the pharmacological effects of lithium on rhythms in cells from Li-R and Li-NR donors. Compared to Li-NRs, Li-Rs showed a difference in chronotype, with higher levels of morningness. Evening chronotype was associated with increased mood symptoms at baseline, including depression, mania, and insomnia. Cells from Li-Rs were more likely to exhibit a short circadian period, a linear relationship between period and phase, and period shortening effects of lithium. Common genetic variation in the IP
Indexed as
Circadian RhythmFibroblastsAdultAnimalsAntimanic AgentsBipolar DisorderCells, CulturedGenotyping TechniquesHumansInositol 1,4,5-Trisphosphate ReceptorsLithium CompoundsLuminescent MeasurementsMiceNIH 3T3 CellsPeriod Circadian ProteinsPolymorphism, Single NucleotideAntimanic AgentsInositol 1,4,5-Trisphosphate ReceptorsITPR3 protein, mouseLithium CompoundsPer2 protein, mousePeriod Circadian Proteins
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