ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
D2 receptors and cognitive flexibility in marmosets: tri-phasic dose-response effects of intra-striatal quinpirole on serial reversal performance.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: remediating effects of dopaminergic D2/3 receptor agents.Psychopharmacology · 2019Trial
- A Comprehensive Study of AAV Tropism in the Marmoset Brain.Neuroscience bulletin · 2026Article
- Comparative effects of inactivation and dopamine receptor agents in the dorsolateral and dorsomedial striatum on performance of action sequences in rats.Psychopharmacology · 2026Article
- Striatal arbitration between choice strategies guides few-shot adaptation.Nature communications · 2025Article
- Opening new vistas on obsessive-compulsive disorder with the observing response task.Cognitive, affective & behavioral neuroscience · 2024Review
- Statistical power and false positive rates for interdependent outcomes are strongly influenced by test type: Implications for behavioral neuroscience.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection.eLife · 2023Article
- Assessing attention and impulsivity in the variable stimulus duration and variable intertrial interval rodent continuous performance test schedules using dopamine receptor antagonists in female C57BL/6JRj mice.Psychopharmacology · 2023Article
- Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection.bioRxiv : the preprint server for biology · 2023Article
- Midbrain dopamine neurons arbiter OCD-like behavior.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dopamine transporter silencing in the rat: systems-level alterations in striato-cerebellar and prefrontal-midbrain circuits.Molecular psychiatry · 2022Article
- Reduced childhood social attention in autism model marmosets predicts impaired social skills and inflexible behavior in adulthood.Frontiers in psychiatry · 2022Article
- Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets.iScience · 2021Article
- The Biology and Pathobiology of Glutamatergic, Cholinergic, and Dopaminergic Signaling in the Aging Brain.Frontiers in aging neuroscience · 2021Review
- Neural bases for attenuation of morphine withdrawal by Heantos-4: role of l-tetrahydropalmatine.Scientific reports · 2020Article
- Dorsal and ventral striatal dopamine D1 and D2 receptors differentially modulate distinct phases of serial visual reversal learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Computational psychopharmacology: a translational and pragmatic approach.Psychopharmacology · 2019Review
- Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence.Psychopharmacology · 2019Article
- Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder.Psychopharmacology · 2019Article
- Accumbal Adenosine AFrontiers in cellular neuroscience · 2019Article
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4 authors at 1 institution in 1 country.
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Abstract
Behavioral flexibility, which allows organisms to adapt their actions in response to environmental changes, is impaired in a number of neuropsychiatric conditions, including obsessive-compulsive disorder and addiction. Studies in human subjects and monkeys have reported correlations between individual differences in dopamine D2-type receptor (D2R) levels in the caudate nucleus and performance in a discrimination reversal task, in which established contingent relationships between abstract stimuli and rewards (or punishments) are reversed. Global genetic deletion of the D2R in mice disrupts reversal performance, indicating a likely causal role for this receptor in supporting flexible behaviors. To directly examine the specific role of caudate D2-type receptors in reversal performance, the D2/3/4R agonist quinpirole was infused via chronic indwelling cannulae into the medial caudate of male and female marmoset monkeys performing a touchscreen-based serial discrimination reversal task. Given prior evidence for dose-dependent effects of quinpirole and other dopaminergic drugs, a full dose-response curve was established. Individually, marmosets displayed marked differences in behavioral sensitivity to specific doses of intra-caudate quinpirole. Collectively, they exhibited a behaviorally specific bi-phasic deficit in reversal learning, being consistently impaired at both relatively low and high doses of quinpirole. However, intermediate doses of intra-caudate quinpirole produced significant improvement in reversal performance. These data support previous human and monkey neuroimaging studies by providing causal evidence of a U-shaped function describing how dopamine modulates cognitive flexibility in the primate striatum.
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