ArticleNature2018
Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1.
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Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers.
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174citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
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Who cites it
174 citing papers in PubMed, 297 citations in OpenAlex.
- Mammalian DNA methyltransferases in DNA methylation and imprinted gene expression in extraembryonic ectoderm of post-implantation embryos.The Journal of biological chemistry · 2026Article
- Reciprocal, methylation-dependent binding of Zfp57 and Gzf1 safeguards Dlk1-Dio3 imprinting during developmental reprogramming.Nature communications · 2026Article
- Cytoplasmic lattices store developmentally poised degradative and cytoskeletal complexes in mammalian eggs.Nature structural & molecular biology · 2026Article
- Epigenetics in development, disease, and therapy: from mechanisms to clinical interventions.Science China. Life sciences · 2026Review
- High-resolution mapping of embryonic genome activation unveils a decoupling of transcription activation from precocious H3K4me3 removal.Science advances · 2026Article
- Stella safeguards proteostasis via regulating UBE2D3 translation in the maternal-to-zygotic transition.Cellular and molecular life sciences : CMLS · 2026Article
- Epigenetic Regulation in Acute Myeloid Leukemia: Molecular Mechanisms and Clinical Implications.Cancers · 2026Review
- Structure of the mouse cytoplasmic lattice.Nature · 2026Article
- Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A review of the association between abnormal body mass index and oocyte quality.Journal of ovarian research · 2026Review
- Selective cellular localization of UHRF1 safeguards mammalian zygotic genome activation and early embryonic development.Cell discovery · 2026Article
- Role of the DNA methyltransferases in diabetes mellitus and Its complications.Molecular biology reports · 2026Review
- DNA Methylation Dynamics in Development and Disease: Insights from Zebrafish Models.Biomedicines · 2026Review
- NLRP14 modulates the activity of E3 ubiquitin ligases during the oocyte-to-embryo transition.Nature communications · 2026Article
- Reprogramming the inactive X chromosome: dynamics and insights from the germline.Biochemical Society transactions · 2026Review
- TCL1A mediates DNA methylation defects in recurrent hydatidiform mole with NLRP7 pathogenic variants.Nature communications · 2026Article
- The maternal PADI6-UHRF1-UBE2D complex regulates ubiquitination during oocyte maturation and embryogenesis.Nature structural & molecular biology · 2026Article
- Nascent transcriptome of embryonic genome activation reveals a regulatory axis linking transcriptional priming to early lineage specification in mouse embryos.Nucleic acids research · 2026Article
- A simple, efficient, and scalable method to generate oocyte-like cells in vitro.Life science alliance · 2026Article
- The superpowers of imprinting control regions.Genome research · 2026Review
114 more citing papers are in PubMed but not listed here.
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Authors and funding
22 authors at 11 institutions in 2 countries.
Yingfeng LiCollege of Life Sciences, Beijing Normal University, Beijing, China.
Zhuqiang ZhangNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Jiayu ChenClinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Wenqiang LiuClinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Weiyi LaiState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Baodong LiuState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Xiang LiNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Liping LiuDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shaohua XuNational Institute of Biological Sciences, Beijing, China.
Qiang DongNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Mingzhu WangClinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Xiaoya DuanShanghai Key Laboratory of Regulatory Biology, Fengxian District Central Hospital-ECNU Joint Center of Translational Medicine, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Jiajun TanNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Yong ZhengNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Pumin ZhangDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Guoping FanDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Jiemin WongShanghai Key Laboratory of Regulatory Biology, Fengxian District Central Hospital-ECNU Joint Center of Translational Medicine, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Guo-Liang XuState Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Zhigao WangDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hailin WangState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Shaorong GaoClinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Bing ZhuNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. zhubing@ibp.ac.cn.
Chinese Academy of Sciences · CNShanghai First Maternity and Infant Hospital · CNEast China Normal University · CNInstitute of Biophysics · CNThe University of Texas Southwestern Medical Center · USUniversity of Chinese Academy of Sciences · CNBaylor College of Medicine · USNational Institute of Biological Sciences, Beijing · CNResearch Center for Eco-Environmental Sciences · CNShanghai Institutes for Biological Sciences · CNUniversity of California, Los Angeles · US
Funding
Dissecting molecular pathways underlying Human Overgrowth SyndromeR01DE025474 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FAN, GUOPING · 2016 to 2020
$1.9MNIDCR NIH HHS R01 DE025474
Abstract
Postnatal growth of mammalian oocytes is accompanied by a progressive gain of DNA methylation, which is predominantly mediated by DNMT3A, a de novo DNA methyltransferase
Indexed as
DNA MethylationEpigenesis, GeneticAnimalsCCAAT-Enhancer-Binding ProteinsCell LineCell NucleusChromosomal Proteins, Non-HistoneDNA (Cytosine-5-)-Methyltransferase 1Embryonic DevelopmentFemaleGenomeHumansMiceNuclear ProteinsOocytesPromoter Regions, GeneticCCAAT-Enhancer-Binding ProteinsChromosomal Proteins, Non-HistoneDNA (Cytosine-5-)-Methyltransferase 1Dnmt1 protein, mouseDppa3 protein, mouseNuclear ProteinsRepressor ProteinsUbiquitin-Protein LigasesUhrf1 protein, mouse
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.