ArticleTranslational psychiatry2018
Abnormal asymmetries in subcortical brain volume in early adolescents with subclinical psychotic experiences.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebral lateral ventricular asymmetry: a meta-analysis and meta-regression of volumetric MRI studies.Neuroradiology · 2026Pooled it
- The role of the globus pallidus subregions in the schizophrenia spectrum continuum.Molecular psychiatry · 2026Article
- Left and Right Hemispheric Lateralization as an Overlooked Variable in Psychiatric Disease: Evidence Across Species.Biological psychiatry · 2026Review
- Assessment of Brain Morphological Abnormalities and Neurodevelopmental Risk Copy Number Variants in Individuals from the UK Biobank.International journal of molecular sciences · 2025Article
- Increased [Journal of neurotrauma · 2024Article
- Longitudinal hippocampal subfield development associated with psychotic experiences in young people.Translational psychiatry · 2024Article
- Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification.Molecular psychiatry · 2023Article
- Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Longitudinal Gray Matter Development Associated With Psychotic Experiences in Young People.Biological psychiatry global open science · 2023Article
- Dynamic effects of bilingualism on brain structure map onto general principles of experience-based neuroplasticity.Scientific reports · 2023Article
- Negative symptoms correlate with altered brain structural asymmetry in amygdala and superior temporal region in schizophrenia patients.Frontiers in psychiatry · 2022Article
- Cortical and Subcortical Structural Morphometric Profiles in Individuals with Nonaffective and Affective Early Illness Psychosis.Schizophrenia bulletin open · 2022Article
- Involvement of cerebellar and subcortical connector hubs in schizophrenia.NeuroImage. Clinical · 2022Article
- Grey and white matter associations of psychotic-like experiences in a general population sample (UK Biobank).Translational psychiatry · 2021Article
- Subcortical Brain Volume Abnormalities in Individuals With an At-risk Mental State.Schizophrenia bulletin · 2020Article
- Two distinct neuroanatomical subtypes of schizophrenia revealed using machine learning.Brain : a journal of neurology · 2020Article
- The contribution of the cingulate cortex: treating depressive symptoms in first-episode drug naïve schizophrenia.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subcortical structures may have an important role in the pathophysiology of psychosis. Our recent mega-analysis of structural magnetic resonance imaging (MRI) data has reported subcortical volumetric and lateralization alterations in chronic schizophrenia, including leftward asymmetric increases in pallidal volume. The question remains, however, whether these characteristics may represent vulnerability to the development of psychosis or whether they are epiphenomena caused by exposure to medication or illness chronicity. Subclinical psychotic experiences (SPEs) occur in some adolescents in the general population and increase the odds of developing psychosis in young adulthood. Investigations into the association between SPEs and MRI-measured volumes of subcortical structures in the general adolescent population would clarify the issue. Here, we collected structural MRI data in a subsample (10.5-13.3 years old) of a large-scale population-based cohort and explored subcortical volume and lateralization alterations related to SPEs (N = 203). Adolescents with SPEs demonstrated significant volumetric increases in the left hippocampus, right caudate, and right lateral ventricle, as well as a marginally significant increase in the left pallidum. Furthermore, adolescents with SPEs showed significantly more leftward laterality of pallidal volume than individuals without SPEs, which replicates our mega-analysis findings in chronic schizophrenia. We suggest that leftward asymmetries in pallidal volume already present in early adolescence may underlie the premorbid predisposition for developing psychosis in later life.
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