Evidence map›Paper›PMID 30487552›Full record

ArticleNature communications2018

The phospholipid PI(3,4)P

Álvaro Román-Fernández, Julie Roignot, Emma Sandilands, Marisa Nacke, Mohammed A Mansour, Lynn McGarry, Emma Shanks, Keith E Mostov, David M Bryant

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. SON-dependent nuclear speckle rehabilitation alleviates proteinopathies.bioRxiv : the preprint server for biology · 2025
    Article
  13. Review
  14. Lysosomal PIPProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Molecular mechanisms of polarized transport to the apical plasma membrane.Frontiers in cell and developmental biology · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Álvaro Román-FernándezInstitute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK.ORCID http://orcid.org/0000-0002-5032-3460
Julie RoignotDepartment of Anatomy, University of California, San Francisco, CA, 94158-2140, USA.
Emma SandilandsInstitute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK.ORCID http://orcid.org/0000-0001-6829-0911
Marisa NackeInstitute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK.
Mohammed A MansourInstitute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK.ORCID http://orcid.org/0000-0001-8701-4007
Lynn McGarryThe CRUK Beatson Institute, Glasgow, G61 1BD, UK.ORCID http://orcid.org/0000-0002-7055-2615
Emma ShanksThe CRUK Beatson Institute, Glasgow, G61 1BD, UK.
Keith E MostovDepartment of Anatomy, University of California, San Francisco, CA, 94158-2140, USA.ORCID http://orcid.org/0000-0002-8123-6247
David M BryantInstitute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK. david.bryant@glasgow.ac.uk.ORCID http://orcid.org/0000-0003-2721-5012
Cancer Research UK Scotland Institute · GBBroad Institute · USTanta University · EGUniversity of California, San Francisco · US

Funding

Research BaseP30DK090868 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI WATNICK, TERRY J · 2010 to 2019
$11.1M
Recovery from acute kidney injuryR01DK074398 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOSTOV, KEITH E · 2007 to 2015
$3.0M
Control of Epithelial PolarityR01DK091530 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOSTOV, KEITH E · 2011 to 2015
$1.7M
ARF GTPase regulation of prostate tumorigenesis: spheroid and in vivo approachesK99CA163535 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRYANT, DAVID MICHAEL · 2012 to 2013
$326k
NCI NIH HHS K99 CA163535NIDDK NIH HHS P30 DK090868NIDDK NIH HHS R01 DK074398NIDDK NIH HHS R01 DK091530NIH HHS K99CA163535NIH HHS R01DK074398NIH HHS R01DK091530
6 · The paper itself

Abstract

Apical-basal polarization is essential for epithelial tissue formation, segregating cortical domains to perform distinct physiological functions. Cortical lipid asymmetry has emerged as a determinant of cell polarization. We report a network of phosphatidylinositol phosphate (PIP)-modifying enzymes, some of which are transcriptionally induced upon embedding epithelial cells in extracellular matrix, and that are essential for apical-basal polarization. Unexpectedly, we find that PI(3,4)P

Indexed as

AnimalsDogsEndosomesIntracellular MembranesMadin Darby Canine Kidney CellsPhosphatidylinositol-3,4,5-Trisphosphate 5-PhosphatasesPhosphatidylinositolsPhosphatidylinositol-3,4,5-Trisphosphate 5-PhosphatasesPhosphatidylinositolsphosphoinositide-3,4-bisphosphate

Identifiers

PMID30487552
PMCPMC6262019
OpenAlexW2901634560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.