ArticleNature communications2018
Intralocus sexual conflict can resolve the male-female health-survival paradox.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The "male-female health-survival paradox" in frail patients undergoing hip replacement.BMC surgery · 2026Article
- Effects and Mechanisms of TikTok Use on Self-Rated Health of Older Adults in China During the COVID-19 Pandemic: A Mediation Analysis.Healthcare (Basel, Switzerland) · 2024Article
- On the resolution of sexual conflict over shared traits.Proceedings. Biological sciences · 2024Review
- Sexual conflict over sex-an underappreciated consequence of childbirth?Evolution, medicine, and public health · 2024Article
- Relationships between digital engagement and the mental health of older adults: Evidence from China.PloS one · 2024Article
- Association between serum lipoprotein(a) and mildly reduced eGFR: a cross-sectional study.BMC nephrology · 2023Article
- Heterogeneous effects of retirement on the biomedical risk factors for cardiovascular and metabolic diseases: New evidence based on the physical examination database in Shanghai, China.SSM - population health · 2023Article
- Sex and gender affect immune aging.Frontiers in aging · 2023Review
- Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics.Ageing research reviews · 2022Review
- Evaluating human autosomal loci for sexually antagonistic viability selection in two large biobanks.Genetics · 2021Article
- Characteristics of Fall-Related Fractures in Older Adults with Cerebrovascular Disease: A Cross-Sectional Study.Clinical interventions in aging · 2021Article
- Observational
- A gene's-eye view of sexual antagonism.Proceedings. Biological sciences · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At any given age, men are more likely to die than women, but women have poorer health at older ages. This is referred to as the "male-female, health-survival paradox", which is not fully understood. Here, we provide a general solution to the paradox that relies on intralocus sexual conflict, where alleles segregating in the population have late-acting positive effects on male fitness, but negative effects on female health. Using an evolutionary modelling framework, we show that male-benefit, female-detriment alleles can spread if they are expressed after female reproduction stops. We provide support for our conflict based solution using experimental Drosophila data. Our results show that selecting for increased late-life male reproductive effort can increase male fitness but have a detrimental effect on female fitness. Furthermore, we show that late-life male fertility is negatively genetically correlated with female health. Our study suggests that intralocus sexual conflict could resolve the health-survival paradox.
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