Evidence map›Paper›PMID 30487263›Full record

SynthesisDiabetes2019

Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control.

Samuela Pollack, Robert P Igo, Richard A Jensen, Mark Christiansen, Xiaohui Li, Ching-Yu Cheng, Maggie C Y Ng, Albert V Smith, Elizabeth J Rossin, Ayellet V Segrè and 68 more

Erratum issuedOpen access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 6 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 6 syntheses or guidelines pooled it, 90 citations in OpenAlex.

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  8. Higher diabetes genetic load in proliferative diabetic retinopathy in South India: The South Indian GeNetics of DiAbeTic Retinopathy (SIGNATR) study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

78 authors at 20 institutions in 14 countries.

Samuela PollackDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Robert P IgoDepartment of Population and Quantitative Health Sciences, Case Western University, Cleveland, OH.
Richard A JensenCardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA.
Mark ChristiansenCardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA.
Xiaohui LiInstitute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Ching-Yu ChengDuke-NUS Medical School, Singapore.ORCID 0000-0003-0655-885X
Maggie C Y NgCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.
Albert V SmithDepartment of Medicine, University of Iceland, Reykjavík, Iceland.
Elizabeth J RossinMassachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA.
Ayellet V SegrèMassachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA.
Samaneh DavoudiMassachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA.
Gavin S TanDuke-NUS Medical School, Singapore.
Yii-Der Ida ChenInstitute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Jane Z KuoInstitute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Latchezar M DimitrovCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.
Lynn K StanwyckMassachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA.
Weihua MengDivision of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee School of Medicine, Scotland, U.K.
S Mohsen HosseiniProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Minako ImamuraLaboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Darryl NousomeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Jihye KimHuman Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
Yang HaiInstitute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Yucheng JiaInstitute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Jeeyun AhnDepartment of Ophthalmology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.
Aaron LeongEndocrine Unit and Diabetes Unit, Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA.
Kaanan ShahSection of Genetic Medicine, University of Chicago, Chicago, IL.
Kyu Hyung ParkDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Eli IppSection of Diabetes and Metabolism, Harbor-UCLA Medical Center, University of California, Los Angeles, Los Angeles, CA.ORCID 0000-0003-1588-0146
Kent D TaylorInstitute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Sharon G AdlerDepartment of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor-University of California, Torrance, CA.
John R SedorDepartment of Medicine, Case Western Reserve University, Cleveland, OH.
Barry I FreedmanSection on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC.ORCID 0000-0003-0275-5530
Family Investigation of Nephropathy and Diabetes-Eye Research Group, DCCT/EDIC Research Group
I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.ORCID 0000-0003-2665-3635
Wayne H-H SheuDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Atsushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Samy HadjadjCHU de Poitiers, Centre d'Investigation Clinique, Poitiers, France.ORCID 0000-0001-7110-6994
Michel MarreUniversité Paris Diderot, Sorbonne Paris Cité, Paris, France.
David-Alexandre TregouetTeam Genomics & Pathophysiology of Cardiovascular Diseases, UPMC, Sorbonne Universités, INSERM, UMR_S 1166, Paris, France.
Roberta Mckean-CowdinDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Rohit VarmaDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Mark I McCarthyOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, U.K.
Leif GroopDepartment of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden.
Emma AhlqvistDepartment of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden.
Valeriya LyssenkoDepartment of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden.
Elisabet AgardhDepartment of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden.
Andrew MorrisUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, U.K.
Alex S F DoneyMolecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, U.K.
Helen M ColhounInstitute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, U.K.ORCID 0000-0002-8345-3288
Iiro ToppilaFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Niina SandholmFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.ORCID 0000-0003-4322-6942
Per-Henrik GroopFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.ORCID 0000-0003-4055-6954
Shiro MaedaLaboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0001-6688-9875
Craig L HanisHuman Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.ORCID 0000-0002-4880-5348
Alan PenmanDepartment of Preventive Medicine, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS.
Ching J ChenDepartment of Ophthalmology, University of Mississippi Medical Center, Jackson, MS.
Heather HancockDepartment of Ophthalmology, University of Mississippi Medical Center, Jackson, MS.
Paul MitchellCentre for Vision Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
Jamie E CraigDepartment of Ophthalmology, Flinders University, Bedford Park, South Australia, Australia.
Emily Y ChewDivision of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD.
Andrew D PatersonInstitute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-9169-118X
Michael A GrassiGrassi Retina, Naperville, IL.
Colin PalmerPat MacPherson Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, U.K.
Donald W BowdenCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.
Brian L YaspanGenentech, Inc., South San Francisco, CA.
David SiscovickInstitute for Urban Health, New York Academy of Medicine, New York, NY.
Mary Frances CotchDivision of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD.
Jie Jin WangDuke-NUS Medical School, Singapore.
Kathryn P BurdonMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Tien Y WongDuke-NUS Medical School, Singapore.
Barbara E K KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI.ORCID 0000-0003-2379-976X
Ronald KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI.ORCID 0000-0002-4428-6237
Jerome I RotterInstitute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Sudha K IyengarDepartment of Population and Quantitative Health Sciences, Case Western University, Cleveland, OH.
Alkes L PriceDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Lucia SobrinMassachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA lucia_sobrin@meei.harvard.edu.ORCID 0000-0003-1575-0819
The Lundquist Institute · USMassachusetts Eye and Ear Infirmary · USLund University · SEWake Forest University · USNinewells Hospital · GBUniversity of Helsinki · FIUniversity of Southern California · USHarvard University · USInserm · FRNational Institutes of Health · USNational Yang Ming Chiao Tung University · TWSingapore National Eye Center · SGThe University of Sydney · AUThe University of Texas Health Science Center at Houston · USUniversity of Mississippi Medical Center · USUniversity of the Ryukyus · JPUniversity of Washington · USUniversity of Wisconsin–Madison · USWestern University of Health Sciences · USCentre for Human Genetics · GB

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Limited Competition for the Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Clinical Research Center (Collaborative U01)U01DK094157 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Ionut Bebu, Barbara Halina Braffett · 2011 to 2026
$97.6M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
ZOVIRAX CREAM TO TREAT HERPES LABIALIS IN ADOLESCENTSM01RR000827 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, R JEFFREY · 1985 to 2010
$74.3M
ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI WANG, CHRISTINA C. · 1985 to 2011
$74.2M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
LOS ANGELES LATINO EYE STUDYU10EY011753 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VARMA, ROHIT · 1998 to 2014
$35.6M
WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WASHBURN, LISA K · 1992 to 2010
$35.2M
Epidemiology of Diabetes Interventions and Complications Data Coordinating CenterU01DK094176 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BEBU, IONUT, BRAFFETT, BARBARA HALINA · 2012 to 2022
$30.8M
ZUNI KIDNEY PROJECT STUDY I--POPULATION BASED SURVEY OF RENAL DISEASEM01RR000997 · NCRR · UNIVERSITY OF NEW MEXICO · PI MOSELEY, POPE L · 1985 to 2010
$30.0M
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6 · The paper itself

Abstract

To identify genetic variants associated with diabetic retinopathy (DR), we performed a large multiethnic genome-wide association study. Discovery included eight European cohorts (

Indexed as

Diabetes Mellitus, Type 2Genome-Wide Association StudyBlood GlucoseDiabetic RetinopathyGenetic Predisposition to DiseaseGenotypeGlycated HemoglobinHumansPolymorphism, Single NucleotideProtein BindingBlood GlucoseGlycated Hemoglobin

Identifiers

PMID30487263
PMCPMC6341299
OpenAlexW2902801700

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.