ArticleProceedings of the National Academy of Sciences of the United States of America2018
Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00137111 (Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia), which is not on this map. Cited by 199 papers.
0numbers the graph read from it
0cells of the map it votes in
199citing papers in PubMed
24.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia
Who cites it
199 citing papers in PubMed, 318 citations in OpenAlex.
- Trial
- Trial
- Fusion gene map of acute leukemia revealed by transcriptome sequencing of a consecutive cohort of 1000 cases in a single center.Blood cancer journal · 2021Trial
- ETV6 Rearrangement Suppresses CDKN1B Transcription by Disrupting an Intragenic Super-enhancer in Acute Lymphoblastic Leukemia.Cancer research · 2026Article
- A genomic and epigenomic lens into the biology of acute lymphoblastic leukaemia.Nature reviews. Cancer · 2026Review
- B-cell precursor acute lymphoblastic leukemia withHaematologica · 2026Article
- Genomic profiling of Mexican patients with B-cell precursor acute lymphoblastic leukemia reveals clinically significant somatic and potential germline variants.The journal of pathology. Clinical research · 2026Article
- The clinical relevance of RAS pathway gene mutations in childhood B-cell acute lymphoblastic leukemia.Annals of hematology · 2026Article
- Chromosomal rearrangement-enhanced mRNA stability drives the oncogenic potential of fusion genes in pediatric leukemia.Haematologica · 2026Article
- Preclinical evaluation of the ROR1-targeting antibody-drug conjugates zilovertamab vedotin and VLS-211 against B-cell ALL patient-derived xenografts.HemaSphere · 2026Article
- Clinical features and initial treatment outcomes of pediatric B-cell acute lymphoblastic leukemia with P2RY8::CRLF2 fusion positivity: a case series.Translational pediatrics · 2026Article
- Deep learning based individualized cross-platform molecular subtype classification of B-lineage acute lymphoblastic leukemia.NPJ precision oncology · 2026Article
- Article
- Advances in the diagnosis and classification of B-ALL: comparative insights from updated guidelines.Blood advances · 2026Article
- Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia.Annals of laboratory medicine · 2026Article
- Pseudogene Coexpression Networks Reveal a Robust Prognostic Signature for Pediatric B-ALL Survival.Cancer research communications · 2026Article
- Article
- IntegrateALL: An end-to-end RNA-seq analysis pipeline for multilevel data extraction and interpretable subtype classification in B-precursor ALL.HemaSphere · 2026Article
- Article
- RanBALL: An Ensemble Machine Learning Framework for Accurate Subtype Identification of Pediatric B-Cell Acute Lymphoblastic Leukemia.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2026Article
139 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 12 institutions in 6 countries.
Jian-Feng LiState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200025 Shanghai, China.ORCID 0000-0003-2349-208X
Yu-Ting DaiState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200025 Shanghai, China.ORCID 0000-0001-8275-2115
Henrik LilljebjörnDepartment of Laboratory Medicine, Division of Clinical Genetics, Lund University, 22184 Lund, Sweden.
Shu-Hong ShenKey Laboratory of Pediatric Hematology and Oncology, Ministry of Health, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 200127 Shanghai, China.
Bo-Wen CuiState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200025 Shanghai, China.
Ling BaiState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200025 Shanghai, China.
Yuan-Fang LiuState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200025 Shanghai, China.
Mao-Xiang QianDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105.
Yasuo KubotaDepartment of Pediatrics, Graduate School of Medicine, The University of Tokyo, 1138654 Tokyo, Japan.
Hitoshi KiyoiDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, 4668550 Nagoya, Japan.
Itaru MatsumuraDivision of Hematology and Rheumatology, Kinki University Faculty of Medicine, 5778502 Osaka, Japan.
Yasushi MiyazakiDepartment of Hematology, Atomic Bomb Disease Institute, Nagasaki University, 8528521 Nagasaki, Japan.
Linda OlssonDepartment of Laboratory Medicine, Division of Clinical Genetics, Lund University, 22184 Lund, Sweden.
Ah Moy TanDepartment of Paediatrics, KK Women's & Children's Hospital, 229899 Singapore.
Hany AriffinPaediatric Haematology-Oncology Unit, University of Malaya Medical Centre, 59100 Kuala Lumpur, Malaysia.
Jing ChenKey Laboratory of Pediatric Hematology and Oncology, Ministry of Health, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 200127 Shanghai, China.
Junko TakitaDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, 6068501 Kyoto, Japan.
Takahiko YasudaClinical Research Center, Nagoya Medical Center, National Hospital Organization, 4600001 Nagoya, Japan.
Hiroyuki ManoNational Cancer Center Research Institute, 1040045 Tokyo, Japan.
Bertil JohanssonDepartment of Laboratory Medicine, Division of Clinical Genetics, Lund University, 22184 Lund, Sweden.
Jun J YangDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105.
Allen Eng-Juh YeohCentre for Translational Research in Acute Leukaemia, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 119228 Singapore.
Fumihiko HayakawaDepartment of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, 4618673 Nagoya, Japan.
Zhu ChenState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200025 Shanghai, China; zchen@stn.sh.cn ching-hon.pui@stjude.org thoas.fioretos@med.lu.se sjchen@stn.sh.cn jinyan@shsmu.edu.cn.
Ching-Hon PuiDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105; zchen@stn.sh.cn ching-hon.pui@stjude.org thoas.fioretos@med.lu.se sjchen@stn.sh.cn jinyan@shsmu.edu.cn.
Thoas FioretosDepartment of Laboratory Medicine, Division of Clinical Genetics, Lund University, 22184 Lund, Sweden; zchen@stn.sh.cn ching-hon.pui@stjude.org thoas.fioretos@med.lu.se sjchen@stn.sh.cn jinyan@shsmu.edu.cn.
Sai-Juan ChenState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200025 Shanghai, China; zchen@stn.sh.cn ching-hon.pui@stjude.org thoas.fioretos@med.lu.se sjchen@stn.sh.cn jinyan@shsmu.edu.cn.
Jin-Yan HuangState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200025 Shanghai, China; zchen@stn.sh.cn ching-hon.pui@stjude.org thoas.fioretos@med.lu.se sjchen@stn.sh.cn jinyan@shsmu.edu.cn.ORCID 0000-0002-8053-0209
Shanghai Jiao Tong University · CNLund University · SESt. Jude Children's Research Hospital · USNagoya University · JPKindai University · JPKK Women's and Children's Hospital · SGKyoto University · JPNagasaki University · JPNational Hospital Organization · JPNational University of Singapore · SGThe University of Tokyo · JPUniversity Malaya Medical Centre · MY
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MCPML - Project 3: Genome-wide Studies of Adverse EffectsP50GM115279 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI RELLING, MARY V · 2015 to 2019
$15.1MPHARMACOGENOMICS OF CHILDHOOD LEUKEMIA (ALL)R37CA036401 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI EVANS, WILLIAM E · 1987 to 2014
$9.7MPharmacogenomics of Childhood Leukemia ALLR01CA036401 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI EVANS, WILLIAM E · 1985 to 2019
$3.6MNCI NIH HHS P30 CA021765NCI NIH HHS R01 CA036401NCI NIH HHS R37 CA036401NIGMS NIH HHS P50 GM115279
Abstract
Most B cell precursor acute lymphoblastic leukemia (BCP ALL) can be classified into known major genetic subtypes, while a substantial proportion of BCP ALL remains poorly characterized in relation to its underlying genomic abnormalities. We therefore initiated a large-scale international study to reanalyze and delineate the transcriptome landscape of 1,223 BCP ALL cases using RNA sequencing. Fourteen BCP ALL gene expression subgroups (G1 to G14) were identified. Apart from extending eight previously described subgroups (G1 to G8 associated with
Indexed as
TranscriptomeAdultChildDatabases, Nucleic AcidFemaleHumansMaleModels, GeneticMutationOncogene FusionOncogene Proteins, FusionPrecursor B-Cell Lymphoblastic Leukemia-LymphomaPrognosisSequence Analysis, RNAOncogene Proteins, FusionBCP ALLgene fusiongene mutationRNA-seqsubtypes
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT00137111ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.