ArticleProceedings of the National Academy of Sciences of the United States of America2018
Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrhythmic Cry-deficient mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
- Chemical biology approaches to study and target circadian clocks and their components.FEBS letters · 2026Review
- Genetic Code Expansion: Recent Developments and Emerging Applications.Chemical reviews · 2025Review
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- Engineering Pyrrolysine Systems for Genetic Code Expansion and Reprogramming.Chemical reviews · 2024Review
- PERfect Day: reversible and dose-dependent control of circadian time-keeping in the mouse suprachiasmatic nucleus by translational switching of PERIOD2 protein expression.The European journal of neuroscience · 2024Article
- Cellular Site-Specific Incorporation of Noncanonical Amino Acids in Synthetic Biology.Chemical reviews · 2024Review
- The Suprachiasmatic Nucleus at 50: Looking Back, Then Looking Forward.Journal of biological rhythms · 2024Review
- Rescue of Comorbid Behavioral and Metabolic Phenotypes of Arrhythmic Mice by Restoring CircadianBiological psychiatry global open science · 2023Article
- Metabolic and chemical architecture of the mammalian circadian clock.Cell chemical biology · 2023Review
- Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly.Annual review of neuroscience · 2023Review
- Article
- Astrocytic control of extracellular GABA drives circadian timekeeping in the suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cryptochrome 1 as a state variable of the circadian clockwork of the suprachiasmatic nucleus: Evidence from translational switching.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mathematical Modeling in Circadian Rhythmicity.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Genetic-code-expanded cell-based therapy for treating diabetes in mice.Nature chemical biology · 2022Article
- Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network.The EMBO journal · 2021Article
- Restoring the Molecular Clockwork within the Suprachiasmatic Hypothalamus of an Otherwise Clockless Mouse Enables Circadian Phasing and Stabilization of Sleep-Wake Cycles and Reverses Memory Deficits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Precise optical control of gene expression ineLife · 2021Article
- Therapeutic promise of engineered nonsense suppressor tRNAs.Wiley interdisciplinary reviews. RNA · 2021Review
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10 authors at 1 institution in 1 country.
Funding
Abstract
The suprachiasmatic nucleus (SCN) is the principal circadian clock of mammals, coordinating daily rhythms of physiology and behavior. Circadian timing pivots around self-sustaining transcriptional-translational negative feedback loops (TTFLs), whereby CLOCK and BMAL1 drive the expression of the negative regulators Period and Cryptochrome (Cry). Global deletion of Cry1 and Cry2 disables the TTFL, resulting in arrhythmicity in downstream behaviors. We used this highly tractable biology to further develop genetic code expansion (GCE) as a translational switch to achieve reversible control of a biologically relevant protein, Cry1, in the SCN. This employed an orthogonal aminoacyl-tRNA synthetase/tRNA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.