ArticlemSphere2018
Tetrasodium EDTA Is Effective at Eradicating Biofilms Formed by Clinically Relevant Microorganisms from Patients' Central Venous Catheters.
Article in mSphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04559334 (Compassionate-Use of 4% T-EDTA Lock Solution for Central Venous Lines of Pediatric PN Patients), which is not on this map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Compassionate-Use of 4% T-EDTA Lock Solution for Central Venous Lines of Pediatric PN Patients
Who cites it
31 citing papers in PubMed.
- Combined High Hydrostatic Pressure and Additive Chemical Treatment Enhances Decontamination Efficiency in Bone Tissue Infected with Staphylococcal Biofilms.Microorganisms · 2026Article
- EDTA suppresses bacterial perseverance to 2-phenoxyethanol.Microbiology spectrum · 2026Article
- Tetrasodium EDTA central venous catheter lock solution in home parenteral nutrition patients: Ease of use and patient satisfaction, a prospective study.The journal of vascular access · 2026Article
- Article
- Single-cell analysis of lipopolysaccharide-mediated heterogeneity in Escherichia coli adhesion and mechanics.Archives of microbiology · 2025Article
- Central venous catheter infections: building a causal model with expert domain knowledge to inform future clinical trials.Antimicrobial resistance and infection control · 2025Article
- Enhanced resistance of metal sequestering agents by reconfiguration of the Staphylococcus aureus cell wall.npj antimicrobials and resistance · 2025Article
- Efficacy of nitric oxide donors and EDTA againstBiofilm · 2025Article
- Use of 4% tetrasodium EDTA (KiteLock™) to prevent central venous catheter-related bloodstream infections in pediatric hemodialysis patients.Pediatric nephrology (Berlin, Germany) · 2025Article
- Biofilm Resilience: Molecular Mechanisms Driving Antibiotic Resistance in Clinical Contexts.Biology · 2025Review
- Drug Clues for the Treatment of Fungal Catheter-Related Bloodstream Infection With Antifungal Lock Therapy.Drug design, development and therapy · 2025Review
- Microbiological analysis of tunneled hemodialysis catheters isolated from patients receiving hemodialysis in Saskatchewan.Future microbiology · 2024Article
- Endodontic irrigants from a comprehensive perspective.World journal of clinical cases · 2024Review
- Article
- Administration of 4% tetrasodium EDTA lock solution and central venous catheter complications in high-risk pediatric patients with intestinal failure: A retrospective cohort study.JPEN. Journal of parenteral and enteral nutrition · 2024Article
- Polymyxin B and ethylenediaminetetraacetic acid act synergistically againstMicrobiology spectrum · 2024Article
- Article
- Enhanced popcorning using polyanionic chelating solutions as irrigation.Urolithiasis · 2023Article
- Tetrasodium EDTA for the prevention of urinary catheter infections and blockages.RSC advances · 2023Article
- Lactobacillus rhamnosus and Staphylococcus epidermidis in gut microbiota: in vitro antimicrobial resistance.AMB Express · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central venous access devices (CVADs) are an essential component of modern health care. However, their prolonged use commonly results in microbial colonization, which carries the potential risk of hospital-acquired bloodstream infections. These infections complicate the treatment of already sick individuals and cost the existing health care systems around the world millions of dollars. The microbes that colonize CVADs typically form multicellular biofilms that are difficult to dislodge and are resistant to antimicrobial treatments. Clinicians are searching for better ways to extend the working life span of implanted CVADs, by preventing colonization and reducing the risk of bloodstream infections. In this study, we analyzed 210 bacterial and fungal isolates from colonized CVADs or human bloodstream infections from two hospitals geographically separated in the east and west of Canada and screened the isolates for biofilm formation
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.