Evidence map›Paper›PMID 30486913›Full record

Observational studyPublic health nutrition2019

Maternal postpartum plasma folate status and preterm birth in a high-risk US population.

Bolanle Olapeju, Ahmed Saifuddin, Guoying Wang, Yuelong Ji, Xiumei Hong, Ramkripa Raghavan, Amber Summers, Amaris Keiser, Hongkai Ji, Barry Zuckerman and 5 more

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Public health nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Bolanle Olapeju1Department of Population, Family and Reproductive Health, Center on Early Life Origins of Disease,Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA.
Ahmed Saifuddin1Department of Population, Family and Reproductive Health, Center on Early Life Origins of Disease,Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA.
Guoying Wang1Department of Population, Family and Reproductive Health, Center on Early Life Origins of Disease,Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA.
Yuelong Ji1Department of Population, Family and Reproductive Health, Center on Early Life Origins of Disease,Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA.
Xiumei Hong1Department of Population, Family and Reproductive Health, Center on Early Life Origins of Disease,Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA.
Ramkripa Raghavan1Department of Population, Family and Reproductive Health, Center on Early Life Origins of Disease,Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA.
Amber Summers2Center for Communication Programs,Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA.
Amaris Keiser3Department of Pediatrics,Johns Hopkins University School of Medicine,615 N. Wolfe Street, E4132, Baltimore, MD 21205-2179,USA.
Hongkai Ji4Department of Biostatistics,Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA.
Barry Zuckerman5Department of Pediatrics,Boston University School of Medicine and Boston Medical Center,Boston, MA,USA.
Christina Yarrington6Department of Obstetrics and Gynecology,Boston University School of Medicine,Boston, MA,USA.
Lingxin Hao7Department of Sociology,Johns Hopkins University,Baltimore, MD,USA.
Pamela J Surkan8Department of International Health,Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA.ORCID 0000-0002-0334-5931
Tina L Cheng3Department of Pediatrics,Johns Hopkins University School of Medicine,615 N. Wolfe Street, E4132, Baltimore, MD 21205-2179,USA.
Xiaobin Wang1Department of Population, Family and Reproductive Health, Center on Early Life Origins of Disease,Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA.
Johns Hopkins University · USBoston University · US

Funding

Preterm Birth, Maternal and Cord Blood Metabolome, and Child Metabolic RiskR01HD041702 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI Frank B Hu, XIAOBIN WANG · 2001 to 2026
$11.1M
Research Infrastructure for the Hopkins Population CenterR24HD042854 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CHERLIN, ANDREW J · 2003 to 2017
$5.1M
Early Life Determinants of Obesity in U.S. Urban Low Income Minority Birth CohortR01HD086013 · NICHD · JOHNS HOPKINS UNIVERSITY · PI LEE, BRUCE Y, WANG, XIAOBIN · 2016 to 2020
$3.3M
Post Genome-Wide Association Study of Food AllergyU01AI090727 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2010 to 2014
$2.3M
DDT, Endocrine Disruption and Reproductive OutcomesR01ES011682 · NIEHS · CHILDREN'S MEMORIAL HOSPITAL (CHICAGO) · PI WANG, XIAOBIN · 2001 to 2003
$926k
Molecular Epidemiology of Preterm BirthR21ES011666 · NIEHS · CHILDREN'S MEMORIAL HOSPITAL (CHICAGO) · PI WANG, XIAOBIN · 2002 to 2004
$562k
Establishing Precursors of Food Allergy in NewbornsR21AI079872 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2008 to 2009
$447k
Epigenome-wide Association Study of Preterm BirthR21HD066471 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2010 to 2011
$354k
NIAID NIH HHS R21 AI079872NIAID NIH HHS U01 AI090727NICHD NIH HHS R01 HD041702NICHD NIH HHS R01 HD086013NICHD NIH HHS R21 HD066471NICHD NIH HHS R24 HD042854NIEHS NIH HHS R01 ES011682NIEHS NIH HHS R21 ES011666
6 · The paper itself

Abstract

objectiveWhile maternal folate deficiency has been linked to poor pregnancy outcomes such as neural tube defects, anaemia and low birth weight, the relationship between folate and preterm birth (PTB) in the context of the US post-folic acid fortification era is inconclusive. We sought to explore the relationship between maternal folate status and PTB and its subtypes, i.e. spontaneous and medically indicated PTB.

designObservational study.

settingBoston Birth Cohort, a predominantly urban, low-income, race/ethnic minority population at a high risk for PTB.ParticipantsMother-infant dyads (n 7675) enrolled in the Boston Birth Cohort. A sub-sample (n 2313) of these dyads had maternal plasma folate samples collected 24-72 h after delivery.

resultsUnadjusted and adjusted logistic regressions revealed an inverse relationship between the frequency of multivitamin supplement intake and PTB. Compared with less frequent use, multivitamin supplement intake 3-5 times/week (adjusted OR (aOR) = 0·78; 95 % CI 0·64, 0·96) or >5 times/week (aOR = 0·77; 95 % CI 0·64, 0·93) throughout pregnancy was associated with reduced risk of PTB. Consistently, higher plasma folate levels (highest v. lowest quartile) were associated with lower risk of PTB (aOR = 0·74; 95 % CI 0·56, 0·97). The above associations were similar among spontaneous and medically indicated PTB.

conclusionsIf confirmed by future studies, our findings raise the possibility that optimizing maternal folate levels across pregnancy may help to reduce the risk of PTB among the most vulnerable US population in the post-folic acid fortification era.

Indexed as

Postpartum PeriodAdultBostonDemographyFemaleFolic AcidHumansPregnancyPregnancy OutcomePremature BirthRisk FactorsSurveys and QuestionnairesUnited StatesVitaminsVulnerable PopulationsFolic AcidVitaminsFolate statusMultivitamin supplementationPreterm birth

Identifiers

PMID30486913
PMCPMC6486449
OpenAlexW2902934421

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.