Evidence map›Paper›PMID 30486869›Full record

ArticleArthritis research & therapy2018

The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic disease.

Yuriy Baglaenko, Nan-Hua Chang, Sindhu R Johnson, Waleed Hafiz, Kieran Manion, Dario Ferri, Babak Noamani, Dennisse Bonilla, Sina Rusta-Sellehy, Larissa Lisnevskaia and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Advanced Autoantibody Testing in Systemic Sclerosis.Diagnostics (Basel, Switzerland) · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Deep Phenotyping of CD11cFrontiers in immunology · 2021
    Article
  14. Article
  15. Article
  16. Urinary Metals Concentrations and Biomarkers of Autoimmunity among Navajo and Nicaraguan Men.International journal of environmental research and public health · 2020
    Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Yuriy BaglaenkoKrembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, Toronto, ON, M5T 2S8, Canada.
Nan-Hua ChangKrembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, Toronto, ON, M5T 2S8, Canada.
Sindhu R JohnsonDivision of Rheumatology, University Health Network, Toronto, ON, Canada.
Waleed HafizDivision of Rheumatology, University Health Network, Toronto, ON, Canada.
Kieran ManionKrembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, Toronto, ON, M5T 2S8, Canada.
Dario FerriKrembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, Toronto, ON, M5T 2S8, Canada.
Babak NoamaniKrembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, Toronto, ON, M5T 2S8, Canada.
Dennisse BonillaKrembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, Toronto, ON, M5T 2S8, Canada.
Sina Rusta-SellehyKrembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, Toronto, ON, M5T 2S8, Canada.
Larissa LisnevskaiaLakeridge Health Services, Oshawa, ON, Canada.
Earl SilvermanDivision of Rheumatology, Sick Children's Hospital, Toronto, ON, Canada.
Arthur BookmanDivision of Rheumatology, University Health Network, Toronto, ON, Canada.
Carolina Landolt-MarticorenaKrembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, Toronto, ON, M5T 2S8, Canada.
Joan WitherKrembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD402, Toronto, ON, M5T 2S8, Canada. Joan.Wither@uhnresearch.ca.ORCID 0000-0001-5961-9228
University Health Network · CALakeridge Health · CAMount Sinai Hospital · CAUniversity of Toronto · CA

Funding

CIHR
6 · The paper itself

Abstract

backgroundDiagnosis of systemic autoimmune rheumatic diseases (SARD) relies on the presence of hallmark anti-nuclear antibodies (ANA), many of which can be detected years before clinical manifestations. However, ANAs are also seen in healthy individuals, most of whom will not develop SARD. Here, we examined a unique cohort of asymptomatic ANA

methodsHealthy ANA

resultsA number of the immunologic abnormalities seen in SARD, including changes in peripheral B (switched memory) and T (iNKT, T regulatory, activated memory T follicular helper) subsets and B cell activation, were also seen in asymptomatic ANA

conclusionsANA production is associated with altered T and B cell activation even in asymptomatic individuals. Some of the currently accepted cellular features of SARD may be associated with ANA production rather than the immunologic events that cause symptoms in SARD.

Indexed as

AdultAgedAntibodies, AntinuclearArthritis, RheumatoidAutoimmune DiseasesB-LymphocytesCohort StudiesFemaleHumansLymphocyte ActivationMaleMiddle AgedPlasma CellsRheumatic DiseasesT-Lymphocytes, Helper-InducerAntibodies, AntinuclearAnti-nuclear antibodiesB cellSystemic autoimmune rheumatic diseaseT cell

Identifiers

PMID30486869
PMCPMC6263058
OpenAlexW2902827638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.