ArticleLipids in health and disease2018
Genome-wide identification and characterization of long non-coding RNAs during postnatal development of rabbit adipose tissue.
Article in Lipids in health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- LncRNAs in domesticated animals: from dog to livestock species.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
- Dynamics of transcriptome and chromatin accessibility revealed sequential regulation of potential transcription factors during the brown adipose tissue whitening in rabbits.Frontiers in cell and developmental biology · 2022Article
- Expression rewiring and methylation of non-coding RNAs involved in rhizome phenotypic variations of lotus ecotypes.Computational and structural biotechnology journal · 2022Article
- Combined analysis of differentially expressed lncRNAs and miRNAs in liver tissues of high-fat fed rabbits by transcriptome sequencing.Frontiers in genetics · 2022Article
- Dynamics of Known Long Non-Coding RNAs during the Maternal-to-Zygotic Transition in Rabbit.Animals : an open access journal from MDPI · 2021Article
- Article
- The role of long noncoding RNAs in livestock adipose tissue deposition - A review.Animal bioscience · 2021Article
- Genome-wide identification and characterization of perirenal adipose tissue microRNAs in rabbits fed a high-fat diet.Bioscience reports · 2021Article
- Sequencing analysis of matrix metalloproteinase 7-induced genetic changes in Schwann cells.Neural regeneration research · 2020Article
- Genome-wide identification and characterization of long non-coding RNAs during differentiation of visceral preadipocytes in rabbit.Functional & integrative genomics · 2020Article
- Screening and identification of MicroRNAs expressed in perirenal adipose tissue during rabbit growth.Lipids in health and disease · 2020Article
- Long Non-Coding RNAs in Brown Adipose Tissue.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe rabbit is widely used as an important experimental model for biomedical research, and shows low adipose tissue deposition during growth. Long non-coding RNAs (lncRNAs) are associated with adipose growth, but little is known about the function of lncRNAs in the rabbit adipose tissue.
methodsDeep RNA-sequencing and comprehensive bioinformatics analyses were used to characterize the lncRNAs of rabbit visceral adipose tissue (VAT) at 35, 85 and 120 days after birth. Differentially expressed (DE) lncRNAs were identified at the three growth stages by DESeq. The cis and trans prediction ways predicted the target genes of the DE lncRNAs. To explore the function of lncRNAs, Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed on the candidate genes.
resultsA total of 991,157,544 clean reads were generated after RNA-Seq of the three growth stages, of which, 30,353 and 107 differentially expressed (DE) lncRNAs were identified. Compared to the protein-coding transcripts, the rabbit lncRNAs shared some characteristics such as shorter length and fewer exons. Cis and trans target gene prediction revealed, 43 and 64 DE lncRNAs respectively, corresponding to 72 and 20 protein-coding genes. GO enrichment and KEGG pathway analyses revealed that the candidate DE lncRNA target genes were involved in oxidative phosphorylation, glyoxylate and dicarboxylate metabolism, and other adipose growth-related pathways. Six DE lncRNAs were randomly selected and validated by q-PCR.
conclusionsThis study is the first to profile the potentially functional lncRNAs in the adipose tissue growth in rabbits, and contributes to our understanding of mammalian adipogenesis.
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