ReviewJournal of biomedical science2018
Sensing acidosis: nociception or sngception?
Review in Journal of biomedical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Causal Connection Between Sng and Muscle Acidosis
Precision Medicine for Sng/Pain Control
Effect of Flow Rate and PH on Muscle Acidosis
The Role of Sngception and Pain in Enhanced Recovery After Surgery (ERAS) for Spine Surgeries
Precision Medicine for Nociception, Sngception and Proprioception.
Who cites it
22 citing papers in PubMed.
- Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Romosozumab mitigates progression from radiological to symptomatic adjacent-level fractures compared to teriparatide.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Contribution of proprioceptors in the mesencephalic trigeminal nucleus and their surrounding astrocytes to acidic saline-induced chronic jaw muscle pain in rodents.Frontiers in cellular neuroscience · 2026Article
- A role for proprioceptors in sngception.Science advances · 2025Article
- Sensory processing in medically unexplained pain syndrome. A systematic review.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- When sng meets acupuncture -- a paradigm-shift biomarker for translational research.Journal of traditional and complementary medicine · 2025Review
- Genetic exploration of roles of acid-sensing ion channel subtypes in neurosensory mechanotransduction including proprioception.Experimental physiology · 2024Review
- Role of proprioceptors in chronic musculoskeletal pain.Experimental physiology · 2024Review
- Astrocyte activation in hindlimb somatosensory cortex contributes to electroacupuncture analgesia in acid-induced pain.Frontiers in neurology · 2024Article
- Amorphous calcium carbonate as a novel potential treatment for osteoarthritis in dogs: a pilot clinical study.Frontiers in veterinary science · 2024Article
- Probing the Effect of Acidosis on Tether-Mode Mechanotransduction of Proprioceptors.International journal of molecular sciences · 2023Article
- Self-assembled innervated vasculature-on-a-chip to study nociception.Biofabrication · 2023Article
- Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia.RMD open · 2023Article
- Development of the Chronic Pain Cognition Scale: A Culture-Sensitive Pain Measurement in Chinese.Journal of pain research · 2023Article
- Acid-sensing ion channel 3 is required for agmatine-induced histamine-independent itch in mice.Frontiers in molecular neuroscience · 2023Article
- Soreness or sng: a common symptom with differential clinical impact from pain in degenerative lumbar spine diseases.BMJ open quality · 2023Article
- Review
- Metabolomic and proteomic characterization of sng and pain phenotypes in fibromyalgia.European journal of pain (London, England) · 2022Article
- In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3.Biochemical pharmacology · 2020Article
- ASIC3-dependent metabolomics profiling of serum and urine in a mouse model of fibromyalgia.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundSensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli. MAIN BODY: In the pain clinic, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset muscle soreness, fibromyalgia, and radicular pain. However, soreness sensation is a sign of successful analgesia for acupuncture and noxipoint therapy. Thus, the nature of acid or soreness sensation is not always nociceptive (or painful) and could be anti-nociceptive. To facilitate the investigation of the molecular and neurobiological mechanisms of soreness sensation, we propose a concept called "sngception (sng- ception)" to describe the response of the somatosensory nervous system to sense tissue acidosis and to distinguish it from nociception. "Sng" is a Taiwanese word that represents the state of soreness while at the same time imitates the natural vocalization of humans feeling sore.
conclusionHere we propose sngception as a specific somatosensory function that transmits the acid sensation from the peripheral to the central nervous system. Sngception could partially overlap with nociception, but it could also transmit antinociception, proprioception, and pruriception.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.