ArticleBMC microbiology2018
The spent culture supernatant of Pseudomonas syringae contains azelaic acid.
Article in BMC microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Lipid peroxidation and stress-induced signalling molecules in systemic resistance mediated by azelaic acid/AZELAIC ACID INDUCED1: signal initiation and propagation.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- Intercropping of tobacco and maize at seedling stage promotes crop growth through manipulating rhizosphere microenvironment.Frontiers in plant science · 2024Article
- Integrated Genomic and Metabolomic Analysis Illuminates Key Secreted Metabolites Produced by the Novel EndophyteMicroorganisms · 2022Article
- Genomic and Metabolomic Insights into Secondary Metabolites of the NovelMicroorganisms · 2021Article
- Genomic Analysis and Secondary Metabolites Production of the EndophyticPlants (Basel, Switzerland) · 2021Article
- Threat at One End of the Plant: What Travels to Inform the Other Parts?International journal of molecular sciences · 2021Review
- AzeR, a transcriptional regulator that responds to azelaic acid inMicrobiology (Reading, England) · 2020Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPseudomonas syringae pv. actinidiae (PSA) is an emerging kiwifruit bacterial pathogen which since 2008 has caused considerable losses. No quorum sensing (QS) signaling molecule has yet been reported from PSA and the aim of this study was to identify possible intercellular signals produced by PSA.
resultsA secreted metabolome analysis resulted in the identification of 83 putative compounds, one of them was the nine carbon saturated dicarboxylic acid called azelaic acid. Azelaic acid, which is a nine-carbon (C9) saturated dicarboxylic acid, has been reported in plants as a mobile signal that primes systemic defenses. In addition, its structure,(which is associated with fatty acid biosynthesis) is similar to other known bacterial QS signals like the Diffusible Signal Facor (DSF). For these reason it could be acting as s signal molecule. Analytical and structural studies by NMR spectroscopy confirmed that in PSA spent supernatants azelaic acid was present. Quantification studies further revealed that 20 μg/L of were present and was also found in the spent supernatants of several other P. syringae pathovars. The RNAseq transcriptome study however did not determine whether azelaic acid could behave as a QS molecule.
conclusionsThis study reports of the possible natural biosynthesis of azelaic acid by bacteria. The production of azelaic acid by P. syringae pathovars can be associated with plant-bacteria signaling.
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