Evidence map›Paper›PMID 30486780›Full record

ArticleBMC genomics2018

Comparative genomics of downy mildews reveals potential adaptations to biotrophy.

Kyle Fletcher, Steven J Klosterman, Lida Derevnina, Frank Martin, Lien D Bertier, Steven Koike, Sebastian Reyes-Chin-Wo, Beiquan Mou, Richard Michelmore

Abstract readComparative Study
In one paragraph

Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
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  5. Genomic and transcriptomic analyses ofFrontiers in microbiology · 2024
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  11. Fungal systematics and evolution · 2022
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  12. Article
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  15. Review
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kyle FletcherThe Genome Center, Genome and Biomedical Sciences Facility, University of California, 451 East Health Sciences Drive, Davis, CA, 95616, USA.
Steven J KlostermanUnited States Department of Agriculture, Agricultural Research Service, Salinas, CA, 93905, USA.
Lida DerevninaThe Genome Center, Genome and Biomedical Sciences Facility, University of California, 451 East Health Sciences Drive, Davis, CA, 95616, USA.
Frank MartinUnited States Department of Agriculture, Agricultural Research Service, Salinas, CA, 93905, USA.
Lien D BertierThe Genome Center, Genome and Biomedical Sciences Facility, University of California, 451 East Health Sciences Drive, Davis, CA, 95616, USA.
Steven KoikeUC Davis Cooperative Extension Monterey County, Salinas, CA, 93901, USA.
Sebastian Reyes-Chin-WoThe Genome Center, Genome and Biomedical Sciences Facility, University of California, 451 East Health Sciences Drive, Davis, CA, 95616, USA.
Beiquan MouUnited States Department of Agriculture, Agricultural Research Service, Salinas, CA, 93905, USA.
Richard MichelmoreThe Genome Center, Genome and Biomedical Sciences Facility, University of California, 451 East Health Sciences Drive, Davis, CA, 95616, USA. rwmichelmore@ucdavis.edu.

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura Marcu · 2002 to 2026
$84.9M
UC Davis Shared Astrios Cell SorterS10OD018223 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SHACKLETT, BARBARA L. · 2015 to 2015
$555k
Shared LSRII Cytometer Equipment Application - UC Davis Stem Cell ProgramS10RR026825 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NOLTA, JAN A. · 2010 to 2010
$500k
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR012088 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI CURRY, FITZ-ROY E · 1996 to 1996
–
NCI NIH HHS P30 CA093373NCRR NIH HHS C06 RR012088NCRR NIH HHS S10 RR026825NIH HHS S10 OD018223Novozymes Inc. Endowed Chair in Genomics
6 · The paper itself

Abstract

backgroundSpinach downy mildew caused by the oomycete Peronospora effusa is a significant burden on the expanding spinach production industry, especially for organic farms where synthetic fungicides cannot be deployed to control the pathogen. P. effusa is highly variable and 15 new races have been recognized in the past 30 years.

resultsWe virulence phenotyped, sequenced, and assembled two isolates of P. effusa from the Salinas Valley, California, U.S.A. that were identified as race 13 and 14. These assemblies are high quality in comparison to assemblies of other downy mildews having low total scaffold count (784 & 880), high contig N

conclusionsWe present a high-quality draft genome of Peronospora effusa that will serve as a reference for Peronospora spp. We identified several Pfam domains as under-represented in the downy mildews consistent with the loss of zoosporegenesis and necrotrophy. Phylogenomics provides further support for a polyphyletic origin of downy mildews.

Indexed as

GenomicsAdaptation, PhysiologicalHeterozygoteLikelihood FunctionsMitochondriaMolecular Sequence AnnotationPeronosporaPhylogenyPlant DiseasesSequence Analysis, RNATerminal Repeat SequencesBiotrophyGene lossGenomicsOomycetePeronospora effusaPeronospora farinosaPeronospora lineageSpinach downy mildew

Identifiers

PMID30486780
PMCPMC6264045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.