SynthesisJournal of the American Heart Association2018
Mitral Valve Prolapse and Sudden Cardiac Death: A Systematic Review.
Synthesis in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- Mitral Valve Prolapse and Sudden Cardiac Death: A Systematic Review.Journal of the American Heart Association · 2018Pooled it
- Hidden Cardiac Channelopathies in Children Presenting with Syncope and Seizure-like Events.Children (Basel, Switzerland) · 2026Article
- Cardiac arrest secondary to mitral annular disjunction: a case report.European heart journal. Case reports · 2026Article
- TClinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Pronounced Mitral Annular Disjunction Is Associated With Increased Postoperative Palpitations After Mitral Valve Surgery for Barlow's Disease.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- Ventricular arrhythmic burden before and after mitral valve repair in mitral valve prolapse: the role of mitral annular disjunction.Frontiers in cardiovascular medicine · 2026Article
- Valvular Heart Disease Associations With Cardiac Biomarkers Using AI-Guided Echocardiography: The RURAL Cohort Study.JACC. Advances · 2026Article
- Does Preliminary Chest Shape Assessment Improve the Prognostic Risk Stratification of Symptomatic Individuals with Primary Mitral Regurgitation? A Narrative Review of Traditional and Innovative Prognostic Indicators.Journal of clinical medicine · 2025Review
- Mitral Valve Prolapse in Athletes: Prevalence, Arrhythmic Associations, and Clinical Implications-A Systematic Review.Journal of clinical medicine · 2025Review
- Phenotyping of Mitral Valve Prolapse Without Severe Mitral Regurgitation Using Electrocardiographic and Echocardiographic Data.JACC. Clinical electrophysiology · 2025Article
- Mitral Valve Prolapse and Sudden Cardiac Death-A Puzzle with Missing Pieces: Review of the Literature and Case Report.Medical sciences (Basel, Switzerland) · 2025Review
- Valvular Heart Disease Associations with Cardiac Biomarkers Using AI-guided Echocardiography: the RURAL Cohort Study.medRxiv : the preprint server for health sciences · 2025Article
- Management of Arrhythmic Mitral Valve Prolapse: Potential Impact and Current Evidence.Reviews in cardiovascular medicine · 2025Review
- Arrhythmogenic mitral valve prolapse-a systematic review of ventricular arrhythmia and sudden cardiac death outcomes before and after mitral valve surgery.Journal of arrhythmia · 2025Article
- Broad Electrocardiogram Syndromes Spectrum: From Common Emergencies to Particular Electrical Heart Disorders-Part II.Diagnostics (Basel, Switzerland) · 2025Review
- Unraveling Mitral Annular Disjunction: A Case Report of Ventricular Arrhythmia Detected via Smartwatch.Reports (MDPI) · 2025Article
- Sudden cardiac death unveiling a mitral annular disjunction in a young man: The role of multimodal cardiac imaging for diagnosis.Journal of cardiology cases · 2025Article
- Multimodality Imaging of Arrhythmic Risk in Mitral Valve Prolapse.Circulation. Cardiovascular imaging · 2025Review
- Does Preliminary Chest Shape Assessment Improve the Prognostic Risk Stratification of Individuals with Mitral Annular Disjunction? A Case Report and Narrative Review.Journal of clinical medicine · 2025Article
- Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background The relationship between mitral valve prolapse ( MVP ) and sudden cardiac death ( SCD ) remains controversial. In this systematic review, we evaluate the relationship between isolated MVP and SCD to better define a potential high-risk subtype. In addition, we determine whether premortem parameters could predict SCD in patients with MVP and the incidence of SCD in MVP . Methods and Results Electronic searches were conducted in PubMed and Embase for all English literature articles published between 1960 and 2018 regarding MVP and SCD or cardiac arrest. We also identified articles investigating predictors of ventricular arrhythmias or SCD and cohort studies reporting SCD outcomes in MVP . From 2180 citations, there were 79 articles describing 161 cases of MVP with SCD or cardiac arrest. The median age was 30 years and 69% of cases were female. Cardiac arrest occurred during situations of stress in 47% and was caused by ventricular fibrillation in 81%. Premature ventricular complexes on Holter monitoring (92%) were common. Most cases had bileaflet involvement (70%) with redundancy (99%) and nonsevere mitral regurgitation (83%). From 22 articles describing predictors for ventricular arrhythmias or SCD in MVP , leaflet redundancy was the only independent predictor of SCD . The incidence of SCD with MVP was estimated at 217 events per 100 000 person-years. Conclusions Isolated MVP and SCD predominantly affects young females with redundant bileaflet prolapse, with cardiac arrest usually occurring as a result of ventricular arrhythmias. To better understand the complex relationship between MVP and SCD , standardized reporting of clinical, electrophysiological, and cardiac imaging parameters with longitudinal follow-up is required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.