ArticleAsian Pacific journal of cancer prevention : APJCP2018
Age-Dependent Differential Expression of Apoptotic Markers in Rat Oral Mucosa
Article in Asian Pacific journal of cancer prevention : APJCP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 13 citations in OpenAlex.
- Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research.Nature communications · 2025Article
- Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies.International journal of molecular sciences · 2020Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
Objective: This study tests the hypothesis that gingival tissue produces age-dependent activation of apoptotic markers. Methods: To address the hypothesis, a prospective experimental study was conducted on 20 adult male albino rats, which were divided into two groups. Group 1 comprised rats aged six months (weighing 150–200 g), and group 2 included old rats aged one year (weighing 250–300 g). Gingival tissue and buccal mucosa biopsy samples were obtained from both groups. Histological and immunohistochemical (Bax apoptotic protein marker) sections were analyzed for both groups. Results: Our data showed a significant decrease in the proliferative activity of oral mucosa (gingiva and buccal mucosa) in old rats and an increase in the immunoreactivity of Bax apoptotic proteins related to increased susceptibility of cells to apoptosis. The mucosal structures (epithelium and lamina propria) were significantly different between the two groups. Furthermore, immunoreactivity for Bax was different between young and old rats. Conclusions: Aging is associated with changes that lead to progressive, irreversible deterioration of the functional capacities of several tissues and organs. Our study demonstrated the effect of age on the histological and apoptotic behavior of oral mucosa (gingiva and buccal mucosa) cells.
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