ArticleAnimals : an open access journal from MDPI2018
Apelin System in Mammary Gland of Sheep Reared in Semi-Natural Pastures of the Central Apennines.
Article in Animals : an open access journal from MDPI, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Effects of graviola oil extract on fattening performance and circadian rhythms of adipokine, cardiac and mitochondrial function markers in lambs.BMC veterinary research · 2026Article
- Diet Supplementation Influences Ghrelin System Expression in the Skin Appendages of the Sheep.Veterinary sciences · 2025Article
- Exploring the potential roles of apelin, visfatin, and irisin in energy regulation in farm animals: an overview.Frontiers in veterinary science · 2024Review
- The effects of apelin on IGF1/FSH-induced steroidogenesis, proliferation, Bax expression, and total antioxidant capacity in granulosa cells of buffalo ovarian follicles.Veterinary research communications · 2023Article
- Presence and localization of apelin and its cognate receptor in canine testes using immunohistochemical and RT-PCR techniques.Veterinary research communications · 2023Article
- Presence, Tissue Localization, and Gene Expression of the Adiponectin Receptor 1 in Testis and Accessory Glands of Male Rams during the Non-Breeding Season.Animals : an open access journal from MDPI · 2023Article
- The Apelinergic System Immuno-Detection in the Abomasum and Duodenum of Sheep Grazing on Semi-Natural Pasture.Animals : an open access journal from MDPI · 2021Article
- Effects of Obesity on Adiponectin System Skin Expression in Dogs: A Comparative Study.Animals : an open access journal from MDPI · 2021Article
- Breast milk apelin level increases with maternal obesity and high-fat feeding during lactation.International journal of obesity (2005) · 2021Article
- Effects of Feed Supplementation on Nesfatin-1, Insulin, Glucagon, Leptin, T3, Cortisol, and BCS in Milking Ewes Grazing on Semi-Natural Pastures.Animals : an open access journal from MDPI · 2021Article
- Leptin System in Obese Dog Skin: A Pilot Study.Animals : an open access journal from MDPI · 2020Article
- Seasonal Expression of NGF and Its Cognate Receptors in the Ovaries of Grey Squirrels (Animals : an open access journal from MDPI · 2020Article
- Influence of Different Feed Physical Forms on Mandibular Gland in Growing Pigs.Animals : an open access journal from MDPI · 2020Article
- Immunohistochemical identification of resistin in the uterus of ewes subjected to different diets: Preliminary results.European journal of histochemistry : EJH · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Sheep are the most bred species in the Central Italy Apennine using the natural pastures as a trophic resource and grazing activity is fundamental to maintain the grassland biodiversity: this goal can be reached only ensuring an economical sustainability to the farmers. This study aimed to investigate the apelin/apelin receptor system in ovine mammary gland and to evaluate the differences induced by food supplementation, in order to shed light on this system function. A flock of 15 Comisana x Appenninica adult dry ewes were free to graze from June until pasture maximum flowering (MxF). From this period to pasture maximum dryness (MxD), in addition to grazing, the experimental group (Exp) was supplemented with 600 g/day/head of cereals. Apelin and apelin receptor were assessed by Real-Time PCR and immunohistochemistry on the mammary glands of subjects pertaining to MxF, MxD and Exp groups. They were detected in alveolar and ductal epithelial cells. The pasture maximum flowering group showed significant differences in apelin expression compared with experimental and MxD groups. Apelin receptor expression significantly differed among the three groups. The reduced apelin receptor expression and immunoreactivity levels during parenchyma involution enables us to hypothesize that apelin receptor plays a modulating role in the system control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.