ArticleNon-coding RNA2018
Cell Type-Selective Expression of Circular RNAs in Human Pancreatic Islets.
Article in Non-coding RNA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- TIGER: The gene expression regulatory variation landscape of human pancreatic islets.Cell reports · 2021Pooled it
- The role of circular RNAs in autoimmune diseases: Potential diagnostic biomarkers and therapeutic targets.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- Circular RNAs in human diseases.MedComm · 2024Review
- β Cell and Autophagy: What Do We Know?Biomolecules · 2023Review
- Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells.Non-coding RNA · 2022Article
- Article
- Circular RNAs in diabetes and its complications: Current knowledge and future prospects.Frontiers in genetics · 2022Review
- Type 1 Diabetes Mellitus-Related circRNAs Regulate CD4+ T Cell Functions.BioMed research international · 2022Article
- Circular RNAs in diabetes mellitus and its complications.Frontiers in endocrinology · 2022Review
- Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis.Frontiers in cell and developmental biology · 2022Review
- Micro-RNA Implications in Type-1 Diabetes Mellitus: A Review of Literature.International journal of molecular sciences · 2021Review
- Circular RNAs as Novel Regulators of β-Cell Functions under Physiological and Pathological Conditions.International journal of molecular sciences · 2021Review
- Comparative Analysis of the Circular Transcriptome in Muscle, Liver, and Testis in Three Livestock Species.Frontiers in genetics · 2021Article
- A circular RNA generated from an intron of the insulin gene controls insulin secretion.Nature communications · 2020Article
- Review
- Article
- Long Noncoding RNAs and Circular RNAs in Autoimmune Diseases.Biomolecules · 2020Review
- Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood.BMC medical genomics · 2020Article
- Circular RNAs in β-cell function and type 2 diabetes-related complications: a potential diagnostic and therapeutic approach.Molecular biology reports · 2019Review
- Integration of Bioinformatic Predictions and Experimental Data to Identify circRNA-miRNA Associations.Genes · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Understanding distinct cell-type specific gene expression in human pancreatic islets is important for developing islet regeneration strategies and therapies to improve β-cell function in type 1 diabetes (T1D). While numerous transcriptome-wide studies on human islet cell-types have focused on protein-coding genes, the non-coding repertoire, such as long non-coding RNA, including circular RNAs, remains mostly unexplored. Here, we explored transcriptional landscape of human α-, β-, and exocrine cells from published total RNA sequencing (RNA-seq) datasets to identify circular RNAs (circRNAs). Our analysis revealed that circRNAs are highly abundant in both α- and β-cells. We identified 10,830 high-confidence circRNAs expressed in human α-, β-, and exocrine cells. The most highly expressed candidates were
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.