Evidence map›Paper›PMID 30486243›Full record

ReviewSports (Basel, Switzerland)2018

Monitoring Exercise-Induced Muscle Fatigue and Adaptations: Making Sense of Popular or Emerging Indices and Biomarkers.

George Theofilidis, Gregory C Bogdanis, Yiannis Koutedakis, Christina Karatzaferi

Abstract readReview
In one paragraph

Review in Sports (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

George TheofilidisMuscle Physiology and Mechanics Group, School of Physical Education and Sports Science, University of Thessaly, Trikala 42100, Greece. gtheofilidis@uth.gr.ORCID 0000-0001-9783-9918
Gregory C BogdanisSchool of Physical Education and Sports Science, National and Kapodistrian University of Athens, Dafne 17237, Greece. gbogdanis@phed.uoa.gr.ORCID 0000-0003-3382-0438
Yiannis KoutedakisHuman Performance Laboratory, School of Physical Education and Sports Science, University of Thessaly, Trikala 42100, Greece. y.koutedakis@uth.gr.ORCID 0000-0002-7065-9447
Christina KaratzaferiMuscle Physiology and Mechanics Group, School of Physical Education and Sports Science, University of Thessaly, Trikala 42100, Greece. karatzaferi.C@gmail.com.ORCID 0000-0002-8266-5780

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regular exercise with the appropriate intensity and duration may improve an athlete's physical capacities by targeting different performance determinants across the endurance⁻strength spectrum aiming to delay fatigue. The mechanisms of muscle fatigue depend on exercise intensity and duration and may range from substrate depletion to acidosis and product inhibition of adenosinetriphosphatase (ATPase) and glycolysis. Fatigue mechanisms have been studied in isolated muscles; single muscle fibers (intact or skinned) or at the level of filamentous or isolated motor proteins; with each approach contributing to our understanding of the fatigue phenomenon. In vivo methods for monitoring fatigue include the assessment of various functional indices supported by the use of biochemical markers including blood lactate levels and more recently redox markers. Blood lactate measurements; as an accompaniment of functional assessment; are extensively used for estimating the contribution of the anaerobic metabolism to energy expenditure and to help interpret an athlete's resistance to fatigue during high intensity exercise. Monitoring of redox indices is gaining popularity in the applied sports performance setting; as oxidative stress is not only a fatigue agent which may play a role in the pathophysiology of overtraining syndrome; but also constitutes an important signaling pathway for training adaptations; thus reflecting training status. Careful planning of sampling and interpretation of blood biomarkers should be applied; especially given that their levels can fluctuate according to an athlete's lifestyle and training histories.

Indexed as

exercise induced muscle fatiguefatigue agentsfatigue indexlactate monitoringmuscle inflammationoxidative stress monitoringredox markerstraining adaptations

Identifiers

PMID30486243
PMCPMC6315493

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.