Evidence map›Paper›PMID 30485818›Full record

ArticleCell reports2018

Promotion of Myoblast Differentiation by Fkbp5 via Cdk4 Isomerization.

Mercedes Ruiz-Estevez, James Staats, Ellen Paatela, Dane Munson, Nobuko Katoku-Kikyo, Ce Yuan, Yoko Asakura, Reilly Hostager, Hiroshi Kobayashi, Atsushi Asakura and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

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  15. Article
  16. Article
  17. FKBP51 and the molecular chaperoning of metabolism.Trends in endocrinology and metabolism: TEM · 2021
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Mercedes Ruiz-EstevezStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.
James StaatsStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Ellen PaatelaStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Dane MunsonStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Nobuko Katoku-KikyoStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Ce YuanStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA; Bioinformatics and Computational Biology Graduate Program, University of Minnesota, Minneapolis, MN 55455, USA.
Yoko AsakuraStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA.
Reilly HostagerStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Hiroshi KobayashiStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Atsushi AsakuraStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: asakura@umn.edu.
Nobuaki KikyoStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: kikyo001@umn.edu.
University of Minnesota · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
Genetically Engineered Muscle Stem Cell Transplantation for Muscular Dystrophy...R01AR062142 · NIAMS · UNIVERSITY OF MINNESOTA · PI ASAKURA, ATSUSHI · 2012 to 2016
$1.6M
Histone isomerization and pluripotencyR01GM098294 · NIGMS · UNIVERSITY OF MINNESOTA · PI KIKYO, NOBUAKI · 2012 to 2015
$1.1M
Transcriptional elongation and long noncoding RNAR21HD083648 · NICHD · UNIVERSITY OF MINNESOTA · PI KIKYO, NOBUAKI · 2016 to 2017
$408k
Engineering iPSC-Derived Skeletal Muscle and Cells for TransplantationR21AR070319 · NIAMS · UNIVERSITY OF MINNESOTA · PI ASAKURA, ATSUSHI · 2016 to 2017
$372k
Long Noncoding RNA and MyogenesisR21AR066158 · NIAMS · UNIVERSITY OF MINNESOTA · PI KIKYO, NOBUAKI · 2015 to 2016
$368k
Hypoxia and long noncoding RNAR21CA187232 · NCI · UNIVERSITY OF MINNESOTA · PI KIKYO, NOBUAKI · 2014 to 2015
$364k
NCI NIH HHS P30 CA077598NCI NIH HHS R21 CA187232NIAMS NIH HHS R01 AR062142NIAMS NIH HHS R21 AR066158NIAMS NIH HHS R21 AR070319NICHD NIH HHS R21 HD083648NIGMS NIH HHS R01 GM098294
6 · The paper itself

Abstract

Fkbp5 is a widely expressed peptidyl prolyl isomerase that serves as a molecular chaperone through conformational changes of binding partners. Although it regulates diverse protein functions, little is known about its roles in myogenesis. We found here that Fkbp5 plays critical roles in myoblast differentiation through two mechanisms. First, it sequesters Cdk4 within the Hsp90 storage complex and prevents the formation of the cyclin D1-Cdk4 complex, which is a major inhibitor of differentiation. Second, Fkbp5 promotes cis-trans isomerization of the Thr172-Pro173 peptide bond in Cdk4 and inhibits phosphorylation of Thr172, an essential step for Cdk4 activation. Consistent with these in vitro findings, muscle regeneration is delayed in Fkbp5

Indexed as

Cell DifferentiationAnimalsCell LineCell ProliferationCyclin-Dependent Kinase 4HSP90 Heat-Shock ProteinsIsomerismMaleMice, KnockoutMusclesMyoblastsPeptidesProlineProtein BindingRegenerationTacrolimus Binding Protein 5Cyclin-Dependent Kinase 4HSP90 Heat-Shock ProteinsPeptidesProlinetacrolimus binding protein 4Tacrolimus Binding Protein 5Tacrolimus Binding ProteinsCdk4cell cyclecell proliferationFkbp4Fkbp5muscle differentiationmuscle regenerationmyoblastpeptidyl prolyl isomerase

Identifiers

PMID30485818
PMCPMC6350781
OpenAlexW2902007899

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.