Evidence map›Paper›PMID 30485442›Full record

ArticlePhotochemistry and photobiology2019

A Novel Prospective Study Assessing the Combination of Photodynamic Therapy and Proton Radiation Therapy: Safety and Outcomes When Treating Malignant Pleural Mesothelioma.

Stephanie R Rice, Yun R Li, Theresa M Busch, Michele M Kim, Sally McNulty, Andrea Dimofte, Timothy C Zhu, Keith A Cengel, Charles B Simone

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Photochemistry and photobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Pleural mesothelioma.Nature reviews. Disease primers · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Photodynamic Therapy: A Brief History.Journal of clinical medicine · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Stephanie R RiceDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD.ORCID 0000-0002-2661-935X
Yun R LiHelen Diller Family Comprehensive Cancer Center, Department of Radiation Oncology, University of California San Francisco, San Francisco, CA.
Theresa M BuschDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Michele M KimDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Sally McNultyDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Andrea DimofteDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Timothy C ZhuDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Keith A CengelDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Charles B SimoneDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD.
University of Pennsylvania · USUniversity of Maryland, Baltimore · USUniversity of California, San Francisco · US

Funding

TUMOR HYPOXIA, PHOTOSENSITIZER, VASCULARITY AND PDTP01CA087971 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BUSCH, THERESA M, CENGEL, KEITH A · 2001 to 2019
$24.8M
Effects of Photodynamic Therapy on Tumor Oxygenation and Blood FlowR01CA085831 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BUSCH, THERESA M · 2001 to 2018
$4.7M
NCI NIH HHS P01 CA087971NCI NIH HHS R01 CA085831
6 · The paper itself

Abstract

Malignant pleural mesothelioma remains difficult to treat, with high failure rates despite optimal therapy. We present a novel prospective trial combining proton therapy (PT) and photodynamic therapy (PDT) and the largest-ever mesothelioma PT experience (n = 10). PDT photosensitizers included porfimer sodium (2 mg·kg

Indexed as

PhotochemotherapyProton TherapyAgedAged, 80 and overCombined Modality TherapyFemaleHumansMaleMesotheliomaMiddle AgedPhotosensitizing AgentsPleural NeoplasmsProspective StudiesTreatment OutcomePhotosensitizing Agents

Identifiers

PMID30485442
PMCPMC6778401
OpenAlexW2902781663

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.