ArticlePloS one2018
Obesity as an effect modifier of the association between menstrual abnormalities and hypertension in young adult women: Results from Project ELEFANT.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Associations of Reproductive Factors With Hypertension Prevalence and Blood Pressure Levels in Female Nurses: A Cross-Sectional Study.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- The interplay between premenstrual syndrome, eating disorder risk, and adiposity indicators: a cross-sectional study.BMC women's health · 2026Article
- Trajectories of menstrual symptoms and blood pressure in midlife: a prospective cohort study on Australian women.Journal of human hypertension · 2025Article
- Dysmenorrhea severity in war refugees with hypertension: a cross-talk with antihypertensives and analgesics.African health sciences · 2023Article
- Associations of Menstrual Cycle Regularity and Length With Cardiovascular Diseases: A Prospective Study From UK Biobank.Journal of the American Heart Association · 2023Article
- Sleep Quality in Women with Premenstrual Syndrome Is Associated with Metabolic Syndrome-Related Variables.Healthcare (Basel, Switzerland) · 2023Article
- Factors associated with the severity of premenstrual symptoms in women with central obesity: a cross-sectional study.Journal of health, population, and nutrition · 2023Article
- Stroke Risk in Young Women with Primary Dysmenorrhea: A Propensity-Score-Matched Retrospective Cohort Study.Journal of personalized medicine · 2023Article
- Risk of Ischemic Heart Disease Associated with Primary Dysmenorrhea: A Population-Based Retrospective Cohort Study.Journal of personalized medicine · 2022Article
- Effects of female obesity on conception, pregnancy and the health of offspring.Frontiers in endocrinology · 2022Review
- Medical Costs of Stroke Care Between Women With and Without Dysmenorrhea: A Population-Based Comparison.Frontiers in public health · 2021Article
- The Relationship between Pain and Vascular Function Biomarkers in Dysmenorrheal University Students.Chonnam medical journal · 2020Article
- Adipokines: A gear shift in puberty.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Review
- Hypertension in Premenopausal and Postmenopausal Women.Current hypertension reports · 2019Review
- Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe menstrual cycle is regulated by reproductive hormones such as estrogen which has been implicated in the pathogenesis of hypertension and is associated with obesity. However, to date there has scant study of hypertension in relation to menstrual characteristics and abnormalities. We hypothesize that adverse menstrual characteristics are associated with an increase the prevalence of hypertension and that this relationship is exacerbated by obesity.
methodsOur study leverages 178,205 healthy female participants (mean age = 29) in a population-based cross-sectional study in Tianjin, China. Menstrual characteristics including menstrual cycle length and regularity, menstrual bleeding length, menstrual blood loss and dysmenorrhea were assessed by self-reported questionnaires, and hypertension was diagnosed by physician. Multiple logistic regression models were used to assess the relationships between menstrual characteristics and hypertension.
resultsNormal length menstrual cycle (OR = 1.21, 95% CI: 1.03-1.41), oligomenorrhea (OR = 1.54, 95% CI: 1.12-2.07), irregular cycle (OR = 1.54, 95% CI: 1.22-1.93), and light menstrual blood loss (OR = 1.36, 95% CI: 1.06-1.72) were associated with hypertension among women who are overweight or obese, but not among women who are normal weight. Longer menstrual bleeding duration (OR = 1.44, 95% CI: 1.24-1.67) and dysmenorrhea were associated with increased prevalence of hypertension (OR = 1.20, 95% CI: 1.14-1.41) in all young women.
conclusionsThe prevalence of hypertension is higher among women with menstrual abnormalities, and this association is modified by overweight and obesity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.