Trial reportPloS one2018
Evaluation of flicker induced hyperemia in the retina and optic nerve head measured by Laser Speckle Flowgraphy.
Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- A New Approach to Retinal Oxygen Extraction Measurement Based on Laser Speckle Flowgraphy and Retinal Oximetry.Translational vision science & technology · 2024Trial
- Sympathetic Stress and Sleep Loss in Diabetic Retinopathy: Links to Retinal Blood-Flow Control.Biomedicines · 2026Review
- Acute Ocular Hypertension Diminishes Flicker-Induced Enhancement in Retinal Blood Flow and Full-Field Electroretinogram in a Mouse Model.Investigative ophthalmology & visual science · 2026Article
- Investigating neurovascular responses of the peripapillary retinal artery to focal flicker stimulation of temporal retinal neurons in the living human eye using AO-OCT.Biomedical optics express · 2026Article
- Effects of flickering light stimulation on retinal blood flow and full-field electroretinogram in mice.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Pericytes in the optic nerve head.Progress in retinal and eye research · 2025Review
- A Method to Evaluate the Frequency Dependence of Retinal Vascular and Neural Metrics to Stimulus Modulation.Translational vision science & technology · 2025Article
- Compact Monocular Video-Ophthalmoscope to Measure Retinal Reflectance Changes to Flicker Light Stimuli.Journal of biophotonics · 2025Article
- Response of capillaries and small arterioles to full-field flicker is not dependent on local ganglion cell thickness.Biomedical optics express · 2025Article
- Stimulus type and duration affect magnitude and evolution of flicker-induced hyperemia measured by laser speckle flowgraphy at the optic disc and peripapillary vessels.Scientific reports · 2024Article
- Central Retinal Artery Occlusion: A Review of Pathophysiological Features and Management.Stroke (Hoboken, N.J.) · 2024Review
- Measuring hyperemic response to light flicker stimulus using continuous laser speckle flowgraphy in mice.Experimental eye research · 2022Article
- Methods to measure blood flow and vascular reactivity in the retina.Frontiers in medicine · 2022Review
- Implication of Retrobulbar and internal carotid artery blood-flow-volume alterations for the pathogenesis of non-arteritic anterior ischemic optic neuropathy.BMC ophthalmology · 2021Article
- Longitudinal Testing of Retinal Blood Flow in a Mouse Model of Hypertension by Laser Speckle Flowgraphy.Translational vision science & technology · 2021Article
- Longitudinal stability of retinal blood flow regulation in response to flicker stimulation and systemic hyperoxia in mice assessed with laser speckle flowgraphy.Scientific reports · 2020Article
- Retinal Neurovascular Coupling in Diabetes.Journal of clinical medicine · 2020Review
- Aortic stiffness is associated with changes in retinal arteriole flow pulsatility mediated by local vasodilation in healthy young/middle-age adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Waveform analysis of human retinal and choroidal blood flow with laser Doppler holography.Biomedical optics express · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
purposeThe coupling between neural activity and blood flow is a physiological key principle of ocular blood flow regulation. The current study was performed to investigate whether Laser speckle flowgraphy (LSFG), a commercially available technique for measuring blood flow, is capable to assess flicker-induced haemodynamic changes in the retinal and optic nerve head (ONH) circulation.
methodsTwenty healthy subjects were included in this cross sectional study. A commercial LSFG instrument was used to measure blood flow at the ONH as well as in retinal vessels before and during stimulation with flickering light. Mean blur rate (MBR), a measure of relative blood flow velocity, was obtained for the ONH and relative flow volume (RFV) a measure of relative blood flow of the respective retinal vessels.
resultsStimulation with flicker light increased ONH MBR by +17.5%±6.6% (p<0.01). In retinal arteries, flicker stimulation led an increase of +23.8±10.0% (p<0.05) in total RFV. For retinal veins, an increase of +23.1%±11.0 (p<0.05) in total RFV was observed during stimulation. A higher response was observed in nasal RFV compared to temporal RFV in retinal arteries (nasal: +28.9%±20.0%; temporal: +20.4%±17.6%, p<0.05) and veins (nasal: +28.3%±19.6%; temporal +17.8%±18.9%, p<0.05).
conclusionAs shown previously with other techniques, flicker stimulation leads to an increase in retinal and optic nerve head blood flow. Our results indicate that LSFG is an appropriate method for the quantification of retinal and ONH blood flow during visual stimulation and may be used as a non-invasive, easy to use tool to assess neuro-vascular coupling in humans.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.