ArticlePLoS computational biology2018
powerTCR: A model-based approach to comparative analysis of the clone size distribution of the T cell receptor repertoire.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Immune signatures underlying post-acute COVID-19 lung sequelae.Science immunology · 2021Trial
- SatTCR: a pipeline for performing saturation analysis of the T cell receptor repertoire and a case study of a healthy canine.MethodsX · 2026Article
- Article
- Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy.Annals of clinical and translational neurology · 2026Article
- Single-cell and clonal analysis of AL amyloidosis plasma cells and their bone marrow microenvironment.Blood · 2025Article
- SURROGATE SELECTION OVERSAMPLES EXPANDED T CELL CLONOTYPES.The annals of applied statistics · 2025Article
- Oligoclonal CD4Communications biology · 2024Article
- Inferring the T cell repertoire dynamics of healthy individuals.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation.The Journal of experimental medicine · 2022Article
- Machine Learning Approaches to TCR Repertoire Analysis.Frontiers in immunology · 2022Review
- Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells.The Journal of experimental medicine · 2021Article
- How Naive T-Cell Clone Counts Are Shaped By Heterogeneous Thymic Output and Homeostatic Proliferation.Frontiers in immunology · 2021Article
- Article
- T cell factor 1: A master regulator of the T cell response in disease.Science immunology · 2020Review
- Needle in a Haystack: The Naïve Repertoire as a Source of T Cell Receptors for Adoptive Therapy with Engineered T Cells.International journal of molecular sciences · 2020Review
- Recipient-specific T-cell repertoire reconstitution in the gut following murine hematopoietic cell transplant.Blood advances · 2020Article
- scRepertoire: An R-based toolkit for single-cell immune receptor analysis.F1000Research · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Sequencing of the T cell receptor (TCR) repertoire is a powerful tool for deeper study of immune response, but the unique structure of this type of data makes its meaningful quantification challenging. We introduce a new method, the Gamma-GPD spliced threshold model, to address this difficulty. This biologically interpretable model captures the distribution of the TCR repertoire, demonstrates stability across varying sequencing depths, and permits comparative analysis across any number of sampled individuals. We apply our method to several datasets and obtain insights regarding the differentiating features in the T cell receptor repertoire among sampled individuals across conditions. We have implemented our method in the open-source R package powerTCR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.