Evidence map›Paper›PMID 30484965›Full record

ArticleMicrobial biotechnology2019

The new strategies to overcome challenges in protein production in bacteria.

Anna Lipońska, Farès Ousalem, Daniel P Aalberts, John F Hunt, Grégory Boël

Abstract read
In one paragraph

Article in Microbial biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anna LipońskaInstitut de Biologie Physico-Chimique, Sorbonne Paris Cité, UMR 8261 CNRS-University Paris Diderot, 13 rue Pierre et Marie Curie, 75005, Paris, France.
Farès OusalemInstitut de Biologie Physico-Chimique, Sorbonne Paris Cité, UMR 8261 CNRS-University Paris Diderot, 13 rue Pierre et Marie Curie, 75005, Paris, France.
Daniel P AalbertsPhysics Department, Williams College, Williamstown, MA, 01267, USA.
John F HuntDepartment of Biological Sciences, Columbia University, New York, NY, 10027, USA.
Grégory BoëlInstitut de Biologie Physico-Chimique, Sorbonne Paris Cité, UMR 8261 CNRS-University Paris Diderot, 13 rue Pierre et Marie Curie, 75005, Paris, France.

Funding

University of Georgia ProjectU54GM094597 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI ROST, BURKHARD · 2010 to 2014
$36.9M
Sub 9 at AECMU54GM075026 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI INOUYE, MASAYORI · 2005 to 2009
$16.8M
Biophysical mechanisms of ABC-F proteinsR01GM120579 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HUNT, JOHN FRANCIS · 2016 to 2019
$1.3M
AREA: Optimizing gene expression with mRNA free energy modeling and algorithmsR15GM106372 · NIGMS · WILLIAMS COLLEGE · PI AALBERTS, DANIEL PAUL · 2014 to 2014
$255k
NIGMS NIH HHS R01 GM120579NIGMS NIH HHS R15 GM106372NIGMS NIH HHS U54 GM075026NIGMS NIH HHS U54 GM094597
6 · The paper itself

Abstract

Recombinant proteins are essential for biotechnology. Here we review some of the key points for improving the production of heterologous proteins, and what can be the future of the field.

Indexed as

BacteriaBiotechnologyMetabolic EngineeringRecombinant ProteinsRecombinant Proteins

Identifiers

PMID30484965
PMCPMC6302713

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.