Evidence map›Paper›PMID 30484648›Full record

ArticleJournal of the American Chemical Society2018

Imaging Insulin Secretion from Mouse Pancreas by MRI Is Improved by Use of a Zinc-Responsive MRI Sensor with Lower Affinity for Zn

André F Martins, Veronica Clavijo Jordan, Filip Bochner, Sara Chirayil, Namini Paranawithana, Shanrong Zhang, Su-Tang Lo, Xiaodong Wen, Piyu Zhao, Michal Neeman and 1 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 79 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. MRI Methods for Imaging Beta-Cell Function in the Rodent Pancreas.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  13. Impact of anFrontiers in endocrinology · 2023
    Article
  14. Using micro-synchrotron radiation x-ray fluorescence (µ-SRXRF) for trace metal imaging in the development of MRI contrast agents for prostate cancer imaging.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Molecular fMRI of neurochemical signaling.Journal of neuroscience methods · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

André F MartinsDepartment of Chemistry and Biochemistry , University of Texas at Dallas , Richardson , Texas 75080 , United States.ORCID 0000-0002-0171-0261
Veronica Clavijo JordanAdvanced Imaging Research Center , University of Texas Southwestern Medical Center , Dallas , Texas 75390-8568 , United States.ORCID 0000-0002-1468-164X
Filip BochnerDepartment of Biological Regulation , The Weizmann Institute of Science , 7610001 Rehovot , Israel.
Sara ChirayilAdvanced Imaging Research Center , University of Texas Southwestern Medical Center , Dallas , Texas 75390-8568 , United States.
Namini ParanawithanaDepartment of Chemistry and Biochemistry , University of Texas at Dallas , Richardson , Texas 75080 , United States.
Shanrong ZhangAdvanced Imaging Research Center , University of Texas Southwestern Medical Center , Dallas , Texas 75390-8568 , United States.
Su-Tang LoAdvanced Imaging Research Center , University of Texas Southwestern Medical Center , Dallas , Texas 75390-8568 , United States.
Xiaodong WenAdvanced Imaging Research Center , University of Texas Southwestern Medical Center , Dallas , Texas 75390-8568 , United States.
Piyu ZhaoDepartment of Chemistry and Biochemistry , University of Texas at Dallas , Richardson , Texas 75080 , United States.
Michal NeemanDepartment of Biological Regulation , The Weizmann Institute of Science , 7610001 Rehovot , Israel.
A Dean SherryDepartment of Chemistry and Biochemistry , University of Texas at Dallas , Richardson , Texas 75080 , United States.ORCID 0000-0001-7150-8301
Southwestern Medical Center · USThe University of Texas at Dallas · USWeizmann Institute of Science · IL

Funding

TR&D 3: Imaging Carbohydrate MetabolismP41EB015908 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2012 to 2021
$10.9M
Imaging Beta Cell Function in Vivo with Zinc Responsive MRI Contrast AgentsR01DK095416 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI SHERRY, DEAN · 2012 to 2021
$3.3M
Avance III HD (AV3) ConsoleS10OD023552 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI TAKAHASHI, MASAYA · 2017 to 2017
$600k
NIBIB NIH HHS P41 EB015908NIDDK NIH HHS R01 DK095416NIH HHS S10 OD023552
6 · The paper itself

Abstract

It has been demonstrated that divalent zinc ions packaged with insulin in β-cell granules can be detected by MRI during glucose-stimulated insulin secretion using a gadolinium-based Zn

Indexed as

AnimalsBinding SitesContrast MediaCoordination ComplexesGadoliniumHumansInsulinInsulin-Secreting CellsInsulin SecretionMagnetic Resonance ImagingMaleMice, Inbred C57BLPancreasProtein BindingSerum Albumin, HumanZincContrast MediaCoordination ComplexesGadoliniumInsulinSerum Albumin, HumanZinc

Identifiers

PMID30484648
PMCPMC6594366
OpenAlexW2902303366

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.