ReviewNatural product reports2019
Nature and nurture: confluence of pathway determinism with metabolic and chemical serendipity diversifies Monascus azaphilone pigments.
Review in Natural product reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed.
- Exogenous glycine promoted the overproduction of extracellular pigments of Monascus purpureus S109 in submerged fermentation.Microbial cell factories · 2026Article
- Simultaneous Production of Bioethanol and Monascus Pigments: a Strategy of Trace Element Supplementation for Monascus purpureus Fermentation.Applied biochemistry and biotechnology · 2026Article
- A centralized database for the genus Monascus: biology, metabolites, and metabolic regulation strategies.Fungal biology and biotechnology · 2026Article
- Research Progress, Safety Regulation and Application Prospects in Health Food Development of Red Yeast Rice-Derived Bioactive Compounds: A Critical Narrative Review.Foods (Basel, Switzerland) · 2026Review
- Microencapsulation of Monascus Red Pigment Using Saccharomyces cerevisiae Ghosts: Process Optimization and Characterization.Probiotics and antimicrobial proteins · 2026Article
- New bioactive pigments and metabolites variation in a liquid culture domesticated Monascus purpureus.Archives of microbiology · 2026Article
- Chromatin-mediated upregulation ofMycology · 2026Article
- Mechanistic Insights from Transcriptomics: How the Glucose TransporterJournal of fungi (Basel, Switzerland) · 2025Article
- Co-Culture ofJournal of fungi (Basel, Switzerland) · 2025Article
- Pigment Formation byJournal of agricultural and food chemistry · 2025Article
- Demethylase MpAlkB2 negatively regulates the growth and positively regulates the synthesis of mycotoxin citrinin in Monascus purpureus.Archives of microbiology · 2025Article
- Exploring the multifaceted roles of histone deacetylase inhibitor vorinostat in the cell growth, mycelial morphology, pigments, and citrinin biosynthesis of Monascus purpureus.Archives of microbiology · 2025Article
- PurifiedJournal of natural products · 2025Review
- Transcriptome Analysis Revealed the Molecular Mechanism of Acetic Acid IncreasingJournal of fungi (Basel, Switzerland) · 2025Article
- Nucleic acid demethylase MpAlkB1 regulates the growth, development, and secondary metabolite biosynthesis in Monascus purpureus.World journal of microbiology & biotechnology · 2024Article
- Exploring the Subcellular Localization ofJournal of fungi (Basel, Switzerland) · 2024Article
- Screening Antibacterial Photodynamic Effect of Monascus Red Yeast Rice (Hong-Qu) and Mycelium Extracts.Current microbiology · 2024Article
- Effects ofJournal of fungi (Basel, Switzerland) · 2024Article
- Taurine-mediated gene transcription and cell membrane permeability reinforced co-production of bioethanol and Monascus azaphilone pigments for a newly isolated Monascus purpureus.Biotechnology for biofuels and bioproducts · 2024Article
- Biosynthesis of Cytosporones in Leotiomycetous Filamentous Fungi.Journal of the American Chemical Society · 2024Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
Covering: up to June 2018 Understanding the biosynthetic mechanisms that generate the astounding structural complexity and variety of fungal secondary metabolites (FSMs) remains a challenge. As an example, the biogenesis of the Monascus azaphilone pigments (MonAzPs) has remained obscure until recently despite the significant medical potential of these metabolites and their long history of widespread use as food colorants. However, a considerable progress has been made in recent years towards the elucidation of MonAzPs biosynthesis in various fungi. In this highlight, we correlate a unified biosynthetic pathway with the diverse structures of the 111 MonAzPs congeners reported until June 2018. We also discuss the origins of structural diversity amongst MonAzPs analogues and summarize new research directions towards exploring novel MonAzPs. The case of MonAzPs illuminates the various ways that FSMs metabolic complexity emerges by the interplay of biosynthetic pathway determinism with metabolic and chemical serendipity.
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