ArticlePhysics in medicine and biology2018
Fast calculation of nanodosimetric quantities in treatment planning of proton and ion therapy.
Article in Physics in medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- An ion treatment planning framework for inclusion of nanodosimetric ionization detail through cluster dose.Medical physics · 2026Article
- One scale to rule them all: interpretable multi-scale Deep Learning for predicting cell survival after proton and carbon ion irradiation.Frontiers in artificial intelligence · 2026Article
- A refined approach to compute nanodosimetric quantities for proton and ion radiotherapy treatment planning.Physics in medicine and biology · 2025Article
- Evaluation of nanodosimetric quantities for ion radiotherapy treatment planning based on the degree of association of survival with cluster dose.Physics in medicine and biology · 2025Article
- Lithium inelastic cross-sections and their impact on micro and nano dosimetry of boron neutron capture.Physics in medicine and biology · 2024Article
- Creating uniform cluster dose spread-out Bragg peaks for proton and carbon beams.Medical physics · 2024Article
- Ionization detail parameters and cluster dose: a mathematical model for selection of nanodosimetric quantities for use in treatment planning in charged particle radiotherapy.Physics in medicine and biology · 2023Article
- GEANT4-DNA simulation of temperature-dependent and pH-dependent yields of chemical radiolytic species.Physics in medicine and biology · 2023Article
- Track Structure of Light Ions: The Link to Radiobiology.International journal of molecular sciences · 2023Article
- Applications of nanodosimetry in particle therapy planning and beyond.Physics in medicine and biology · 2021Review
- Independent reaction times method in Geant4-DNA: Implementation and performance.Medical physics · 2020Article
- Monte Carlo track-structure for the radionuclide Copper-64: characterization of S-values, nanodosimetry and quantification of direct damage to DNA.Physics in medicine and biology · 2020Article
- Simultaneous optimization of RBE-weighted dose and nanometric ionization distributions in treatment planning with carbon ions.Physics in medicine and biology · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Details of the pattern of ionization formed by particle tracks extends knowledge of dose effects on the nanometer scale. Ionization detail (ID), frequently characterized by ionization cluster size distributions (ICSD), is obtained through time-consuming Monte Carlo (MC) track-structure simulations. In this work, TOPAS-nBio was used to generate a highly precise database of biologically significant ID quantities, sampled with randomly oriented 2.3 nm diameter cylinders, 3.4 nm (10 base pairs) long, inside a chromatin-size cylinder, irradiated by 1-1000 MeV/u ions of Z = 1-8. A macroscopic method developed to utilize the database using condensed-history MC was used to calculate distributions of the ICSD first moment [Formula: see text] and cumulative probability [Formula: see text] in a 20 × 20 × 40 cm
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