Evidence map›Paper›PMID 30484388›Full record

ArticleTissue engineering. Part A2019

Substrate Elasticity Governs Differentiation of Renal Tubule Cells in Prolonged Culture.

Harold D Love, Mingfang Ao, Seiver Jorgensen, Lindsey Swearingen, Nicholas Ferrell, Rachel Evans, Leslie Gewin, Raymond C Harris, Roy Zent, Shuvo Roy and 1 more

Open access · greenAbstract read
In one paragraph

Article in Tissue engineering. Part A, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Breaking the symmetry of cell contractility drives tubulogenesis via CXCL1 polarization.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Harold D Love1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Mingfang Ao1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Seiver Jorgensen2College of Arts and Science, Vanderbilt University, Nashville, Tennessee.
Lindsey Swearingen2College of Arts and Science, Vanderbilt University, Nashville, Tennessee.
Nicholas Ferrell1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Rachel Evans1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Leslie Gewin1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Raymond C Harris1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Roy Zent1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Shuvo Roy3Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California.
William H Fissell1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Vanderbilt University Medical Center · USVanderbilt University · USUniversity of California, San Francisco · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3M
Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
The Role of the EGF Receptor in Acute and Chronic Renal InjuryR01DK051265 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 1997 to 2026
$10.1M
The Laminin Receptors in Kidney FibrosisR01DK069921 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROY ZENT · 2005 to 2026
$9.5M
The role of the innate immune cell cyclooxygenase/prostaglandin system in blood pressureregulationR01DK062794 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 2003 to 2026
$9.4M
The Role of renal macrophages in recovery from renal injuryR01DK095785 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 2013 to 2026
$6.7M
Novel Integrated Analyses of Human Diabetic NephropathyR24DK103067 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CAPRIOLI, RICHARD M, DENNY, JOSHUA C. · 2014 to 2018
$6.5M
Vanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3M
Building an Implantable Artificial KidneyU01EB021214 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FISSELL, WILLIAM H, ROY, SHUVO · 2015 to 2018
$6.0M
BLRD VA I01 BX002198BLRD VA I01 BX003425NCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NIBIB NIH HHS U01 EB021214NIBIB NIH HHS U01 EB025136NIDDK NIH HHS K01 DK092357NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS P30 DK114809NIDDK NIH HHS R01 DK051265NIDDK NIH HHS R01 DK062794NIDDK NIH HHS R01 DK069921NIDDK NIH HHS R01 DK095785NIDDK NIH HHS R01 DK108968NIDDK NIH HHS R03 DK110399NIDDK NIH HHS R24 DK103067NIDDK NIH HHS T32 DK007569NIDDK NIH HHS U24 DK059637NIDDK NIH HHS U2C DK059637
6 · The paper itself

Abstract

impact statementSuccessful clinical tissue engineering requires functional fidelity of the cultured cell to its

Indexed as

Cell DifferentiationElasticityAnimalsAquaporinsCell ProliferationCells, CulturedCell ShapeHumansHydrogelsKidney TubulesMiceReceptors, Transforming Growth Factor betaSignal TransductionSodium-Hydrogen Exchanger 3Transforming Growth Factor betaAquaporinsHydrogelsReceptors, Transforming Growth Factor betaSLC9A3 protein, humanSodium-Hydrogen Exchanger 3Transforming Growth Factor betamatrix elasticityNHE3renal tubule cell

Identifiers

PMID30484388
PMCPMC6648172
OpenAlexW2903334041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.