Evidence map›Paper›PMID 30484350›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Renal olfactory receptor 1393 contributes to the progression of type 2 diabetes in a diet-induced obesity model.

Blythe D Shepard, Hermann Koepsell, Jennifer L Pluznick

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. GPR39 activation inhibits AQP2 trafficking and alters cytoskeletal organization.American journal of physiology. Cell physiology · 2026
    Article
  3. Article
  4. Renal Ghrelin-Family GPR39 Receptor and Urinary Concentrating Ability.Journal of the American Society of Nephrology : JASN · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. The sugar daddy: the role of the renal proximal tubule in glucose homeostasis.American journal of physiology. Cell physiology · 2022
    Review
  10. Article
  11. Review
  12. Article
  13. Landscape of GPCR expression along the mouse nephron.American journal of physiology. Renal physiology · 2021
    Article
  14. Article
  15. Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  16. Article
  17. Article
  18. Sex differences in diabetes and kidney disease: mechanisms and consequences.American journal of physiology. Renal physiology · 2019
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Blythe D ShepardDepartment of Physiology, Johns Hopkins University School of Medicine , Baltimore, Maryland.
Hermann KoepsellDepartment of Molecular Plant Physiology and Biophysics, Julius-von Sachs-Institute, University Wurzburg , Wurzburg , Germany.
Jennifer L PluznickDepartment of Physiology, Johns Hopkins University School of Medicine , Baltimore, Maryland.
Johns Hopkins University · US

Funding

Elucidating the Role of Olfactory Receptor 1393 in Renal Glucose HandlingK01DK106400 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SHEPARD, BLYTHE D · 2016 to 2021
$657k
NIDDK NIH HHS K01 DK106400
6 · The paper itself

Abstract

Olfactory receptors are G protein-coupled receptors that serve to detect odorants in the nose. Additionally, these receptors are expressed in other tissues, where they have functions outside the canonical smell response. Olfactory receptor 1393 (Olfr1393) was recently identified as a novel regulator of Na

Indexed as

Diet, High-FatRenal ReabsorptionAnimalsBlood GlucoseDiabetes Mellitus, Type 2Disease Models, AnimalDisease ProgressionFemaleGlomerular Filtration RateInsulin ResistanceKidney Tubules, ProximalMaleMice, KnockoutObesityReceptors, OdorantTime FactorsBlood GlucoseOlfr1393 protein, mouseReceptors, Odorantdiabetesglucose tolerancehyperfiltrationolfactory receptorSglt1

Identifiers

PMID30484350
PMCPMC6397369
OpenAlexW2903365177

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.