Evidence map›Paper›PMID 30484345›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Patients with hypokalemia develop WNK bodies in the distal convoluted tubule of the kidney.

Martin N Thomson, Wolfgang Schneider, Kerim Mutig, David H Ellison, Ralph Kettritz, Sebastian Bachmann

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Potassium and the kidney.Nature reviews. Nephrology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. The evolving concepts of KS-WNK1 effect on NCC activity.American journal of physiology. Renal physiology · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. KS-WNK1 is required for the renal response to extreme changes in potassium intake.American journal of physiology. Renal physiology · 2024
    Article
  12. Review
  13. Potassium homeostasis: sensors, mediators, and targets.Pflugers Archiv : European journal of physiology · 2022
    Review
  14. WNK4 kinase: from structure to physiology.American journal of physiology. Renal physiology · 2021
    Review
  15. Article
  16. Article
  17. Review
  18. WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia.American journal of physiology. Renal physiology · 2020
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Martin N ThomsonDepartment of Anatomy, Charité-Universitätsmedizin Berlin, Berlin , Germany.
Wolfgang SchneiderDepartment of Pathology, Charité-Universitätsmedizin Berlin, Berlin , Germany.
Kerim MutigDepartment of Anatomy, Charité-Universitätsmedizin Berlin, Berlin , Germany.ORCID 0000-0001-9006-5112
David H EllisonDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health & Science University , Portland, Oregon.ORCID 0000-0003-2915-265X
Ralph KettritzNephrology and Medical Intensive Care Medicine, Charité-Universitätsmedizin Berlin, Berlin , Germany.
Sebastian BachmannDepartment of Anatomy, Charité-Universitätsmedizin Berlin, Berlin , Germany.

Funding

WNK Kinase Regulation of Thiazide-sensitive NaCl TransportR01DK051496 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI David Hoadley Ellison, CHAO-LING YANG · 1998 to 2026
$8.4M
Role of Kir4.1 in Regulating NCC and ROMK in DCTR01DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2001 to 2020
$7.4M
Renal Effects of AldosteroneI01BX002228 · VA · PORTLAND VA MEDICAL CENTER · PI ELLISON, DAVID H · 2014 to 2021
–
BLRD VA I01 BX002228NIDDK NIH HHS R01 DK051496NIDDK NIH HHS R01 DK054983
6 · The paper itself

Abstract

Hypokalemia contributes to the progression of chronic kidney disease, although a definitive pathophysiological theory to explain this remains to be established. K

Indexed as

BiomarkersCase-Control StudiesHumansHypokalemiaKidney DiseasesKidney Tubules, DistalMultienzyme ComplexesPotassiumProtein Serine-Threonine KinasesWNK Lysine-Deficient Protein Kinase 1BiomarkersMultienzyme ComplexesPotassiumProtein Serine-Threonine KinasesSTK39 protein, humanWNK1 protein, humanWNK4 protein, humanWNK Lysine-Deficient Protein Kinase 1hypokalemic nephropathymicrotubulesNCCSPAKtrafficking

Identifiers

PMID30484345
PMCPMC6397373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.