Evidence map›Paper›PMID 30484323›Full record

ArticleAntioxidants & redox signaling2019

Isosteviol Protects Free Fatty Acid- and High Fat Diet-Induced Hepatic Injury

Hongwei Yi, Deyi Xu, Xudong Wu, Fang Xu, Lin Lin, Huiping Zhou

Abstract read
In one paragraph

Article in Antioxidants & redox signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. The p66International journal of molecular sciences · 2023
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hongwei Yi1 Department of Pharmacology, School of Medicine, Southeast University, Nanjing, China.
Deyi Xu1 Department of Pharmacology, School of Medicine, Southeast University, Nanjing, China.
Xudong Wu2 State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
Fang Xu2 State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
Lin Lin1 Department of Pharmacology, School of Medicine, Southeast University, Nanjing, China.
Huiping Zhou3 Department of Microbiology and Immunology, Virginia Commonwealth University and McGuire Veterans Affairs Medical Center, Richmond, Virginia.

Funding

Regulation of Hepatic SphK2 by Bile Acids: Effects on Lipid MetabolismR01DK057543 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI HYLEMON, PHILLIP B, ZHOU, HUIPING ROSE · 2001 to 2015
$4.4M
LncRNA H19 in Cholestatic Liver DiseasesR01DK115377 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI HYLEMON, PHILLIP B, ZHOU, HUIPING ROSE · 2018 to 2021
$2.1M
Bile Acid and Sphingosine-1-phosphate Receptor-mediated Signaling in CholestasisR01DK104893 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI HYLEMON, PHILLIP B, ZHOU, HUIPING ROSE · 2016 to 2020
$2.0M
Impact of Alcohol on HIV Protease Inhibitor-induced ER Stress and LipotoxicityI01BX001390 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI ZHOU, HUIPING ROSE · 2012 to 2015
–
Mechanisms of Berberine for the Treatment of Non-Alcoholic Fatty Liver DiseaseI01BX004033 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI ZHOU, HUIPING ROSE · 2018 to 2021
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BLR&D Research Career Scientist Award ApplicationIK6BX004477 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI HUIPING ZHOU · 2019 to 2026
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BLRD VA I01 BX001390BLRD VA I01 BX004033BLRD VA IK6 BX004477NIDDK NIH HHS R01 DK057543NIDDK NIH HHS R01 DK104893NIDDK NIH HHS R01 DK115377
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsApoptosisBiopsyDiet, High-FatDisease Models, AnimalDiterpenes, KauraneEndoplasmic Reticulum StressFatty Acids, NonesterifiedGene Knockdown TechniquesHepatocytesLipid MetabolismMitochondriaNon-alcoholic Fatty Liver DiseaseOxidative StressProtein Kinase C betaRatsDiterpenes, KauraneFatty Acids, NonesterifiedisosteviolProtein Kinase C betaReactive Oxygen SpeciesShc1 protein, mouseSrc Homology 2 Domain-Containing, Transforming Protein 1ER stressfree fatty acidIsosteviolNAFLDROS

Identifiers

PMID30484323
PMCPMC6486675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.