Evidence map›Paper›PMID 30484263›Full record

ArticlePathology oncology research : POR2019

Expression and Significance of TRIM 28 in Squamous Carcinoma of Esophagus.

Bo Liu, Xiujuan Li, Fengxi Liu, Fengyu Li, Shuxia Wei, Junchao Liu, Yang Lv

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathology oncology research : POR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Low-Molecular-WeightFood science & nutrition · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Multifaceted role ofMedComm · 2024
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class.Chembiochem : a European journal of chemical biology · 2021
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Bo LiuDepartment of Pathology, First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China.
Xiujuan LiDepartment of Histology and Embryology, Hebei North University, 11 Zuanshi South Road, Zhangjiakou, 075000, Hebei, China.
Fengxi LiuDepartment of Histology and Embryology, Hebei North University, 11 Zuanshi South Road, Zhangjiakou, 075000, Hebei, China.
Fengyu LiDepartment of Oncology, No.251 Hospital of the Chinese People's Liberation Army, Zhangjiakou, 075000, China.
Shuxia WeiDepartment of Oncology, No.251 Hospital of the Chinese People's Liberation Army, Zhangjiakou, 075000, China.
Junchao LiuDepartment of Pathology, First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China.
Yang LvDepartment of Histology and Embryology, Hebei North University, 11 Zuanshi South Road, Zhangjiakou, 075000, Hebei, China. hbbfxy_lvyang@163.com.ORCID http://orcid.org/0000-0001-6914-9776
Hebei North University · CNChinese People 's Liberation Army No. 85 Hospital · CN

Funding

the science and technology supporting plan in Hebei Province 15277707Dthe science research project of Science and Technology Bureau of Zhangjiakou 1712003D
6 · The paper itself

Abstract

Tripartite motif-containing protein 28 (TRIM28) has been proved to accelerate cell proliferation and metastasis in a variety of human cancers. However, the role of TRIM28 in esophageal squamous cell carcinoma (ESCC) remains unclear. In this study, to compare the biological effect and significance of TRIM28 expression in ESCC, immunohistochemistry (streptavidin-perosidase, S-P) method was used firstly to examine the expression of TRIM28 in 136 cases of ESCC, 35 cases of high grade intraepithelial neoplasia (HGIN), 29 cases of low grade intraepithelial neoplasia (LGIN) and 37 cases of normal esophageal epithelium (NEE). Then the associations of TRIM28 expression with clinicopathological data and overall survival (OS) were also analyzed. Western blot was performed to evaluate TRIM28 protein in a total of 20 matched human ESCC and NEE tissues. Moreover, the localization of TRIM28 protein in ESCC and NEE tissues was also detected by immunofluorescence. TRIM28 protein was mainly distributed in the nucleus of ESCC. The expression of TRIM28 increased progressively from NEE to LGIN, to HGIN, and to ESCC, and it was also related to invasive depth, pTNM stage and lymph node metastasis in ESCC (P < 0.05). The results of western blot and immunofluorescence all showed that the relative expression of TRIM28 protein was markedly upregulated in ESCC compared with the NEE tissues (P < 0.01). However, prognostic analysis showed that TRIM28 may not be a prognostic factor of patients with ESCC. In conclusion, the overexpression of TRIM28 may play an important role for development and metastasis in ESCC.

Indexed as

Gene Expression Regulation, NeoplasticAdultAgedBiomarkers, TumorCarcinoma in SituEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleFollow-Up StudiesHumansLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessPrognosisSurvival RateBiomarkers, TumorTRIM28 protein, humanTripartite Motif-Containing Protein 28Esophageal squamous cell carcinomaImmunofluorescenceImmunohistochemistryOverall survivalTRIM28Western blot

Identifiers

PMID30484263
PMCPMC6815281
OpenAlexW2903248451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.