Evidence map›Paper›PMID 30484258›Full record

ArticleDrug delivery and translational research2019

Pectin-encrusted gold nanocomposites containing phytic acid and jacalin: 1,2-dimethylhydrazine-induced colon carcinogenesis in Wistar rats, PI3K/Akt, COX-2, and serum metabolomics as potential targets.

Malti Arya, Pooja Singh, Chandra B Tripathi, Poonam Parashar, Mahendra Singh, Jovita Kanoujia, Anupam Guleria, Gaurav Kaithwas, Krishna P Gupta, Shubhini A Saraf

Abstract read
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Article in Drug delivery and translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Malti AryaDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (BBAU), A Central University, Vidya Vihar, Raebareli Road, Lucknow, UP, 226025, India.
Pooja SinghDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (BBAU), A Central University, Vidya Vihar, Raebareli Road, Lucknow, UP, 226025, India.
Chandra B TripathiDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (BBAU), A Central University, Vidya Vihar, Raebareli Road, Lucknow, UP, 226025, India.
Poonam ParasharDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (BBAU), A Central University, Vidya Vihar, Raebareli Road, Lucknow, UP, 226025, India.
Mahendra SinghDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (BBAU), A Central University, Vidya Vihar, Raebareli Road, Lucknow, UP, 226025, India.
Jovita KanoujiaDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (BBAU), A Central University, Vidya Vihar, Raebareli Road, Lucknow, UP, 226025, India.
Anupam GuleriaCentre of Biomedical Research (CBMR), Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS) Campus, Raebareli Road, Lucknow, UP, 226014, India.
Gaurav KaithwasDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (BBAU), A Central University, Vidya Vihar, Raebareli Road, Lucknow, UP, 226025, India.
Krishna P GuptaDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (BBAU), A Central University, Vidya Vihar, Raebareli Road, Lucknow, UP, 226025, India.
Shubhini A SarafDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (BBAU), A Central University, Vidya Vihar, Raebareli Road, Lucknow, UP, 226025, India. shubhini.saraf@gmail.com.ORCID http://orcid.org/0000-0002-4180-0931
Babasaheb Bhimrao Ambedkar University · INSanjay Gandhi Post Graduate Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phytic acid (PA) has momentous chemotherapeutic potential. Due to the chelate formation and rapid elimination, it is not popular in cancer treatment. The present work was inquested to develop a surface-modified nanoformulation of PA which prevents its speedy elimination and maximizes chemotherapeutic action. Chloroauric acid was reduced with pectin to produce pectin-gold nanoparticles (PGNPs). PGNPs were incubated with PA and jacalin for drug loading and surface modifications, respectively, to form PA-loaded jacalin-pectin-gold nanoparticles (PA-J-PGNPs). Formulation(s) were assessed for various pharmaceutical/pharmacological parameters. To validate the efficacy against colon carcinogenesis, formulation(s) were assessed in 1,2-dimethylhydrazine (DMH)-treated Wistar rats. DMH treatment distorted colonic architecture, oxidative, and hemodynamic parameters, which were favorably restored by PA-J-PGNP administration. To further confirm our deliberations, formulation(s) were also examined against DMH-altered metabolic changes and expression of markers pertaining to cellular proliferation, which was reinstated by PA-J-PGNPs. Our findings establish PA formulation(s) as a promising approach for suppression of colon carcinogenesis.

Indexed as

1,2-DimethylhydrazineAnimalsChloridesColonic NeoplasmsCyclooxygenase 2Drug CompoundingGene Expression Regulation, NeoplasticGold CompoundsMetabolomicsMetal NanoparticlesPhosphatidylinositol 3-KinasesPhytic AcidPlant LectinsProto-Oncogene Proteins c-aktRatsRats, Wistar1,2-DimethylhydrazineChloridesCyclooxygenase 2Gold Compoundsgold tetrachloride, acidjacalinPhosphatidylinositol 3-KinasesPhytic AcidPlant LectinsProto-Oncogene Proteins c-akt1H NMR spectroscopyHemodynamic changesIP6RT-PCRSurface modificationWestern blotting

Identifiers

PMID30484258
OpenAlexW2902828083

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.