Evidence map›Paper›PMID 30483864›Full record

ArticleInternational journal of colorectal disease2019

The effect of pasireotide on intestinal anastomotic healing with and without whole-body irradiation in a rat model.

Gabriel J Seifert, Gunnar Leithold, Birte Kulemann, Philipp A Holzner, Torben Glatz, Jens Hoeppner, Simon Kirste, Goran Marjanovic, Claudia Laessle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of colorectal disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gabriel J SeifertDepartment of General and Visceral Surgery, Medical Centre - University of Freiburg, Faculty of Medicine, University Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany. gabriel.seifert@uniklinik-freiburg.de.
Gunnar LeitholdDepartment of General and Visceral Surgery, Medical Centre - University of Freiburg, Faculty of Medicine, University Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
Birte KulemannDepartment of General and Visceral Surgery, Medical Centre - University of Freiburg, Faculty of Medicine, University Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
Philipp A HolznerDepartment of General and Visceral Surgery, Medical Centre - University of Freiburg, Faculty of Medicine, University Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
Torben GlatzDepartment of General and Visceral Surgery, Medical Centre - University of Freiburg, Faculty of Medicine, University Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
Jens HoeppnerDepartment of General and Visceral Surgery, Medical Centre - University of Freiburg, Faculty of Medicine, University Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
Simon KirsteDepartment of Radiooncology, Medical Centre - University of Freiburg, Faculty of Medicine, University Freiburg, Robert-Koch-Str. 3, 79106, Freiburg, Germany.
Goran MarjanovicDepartment of General and Visceral Surgery, Medical Centre - University of Freiburg, Faculty of Medicine, University Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
Claudia LaessleDepartment of General and Visceral Surgery, Medical Centre - University of Freiburg, Faculty of Medicine, University Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine pasireotide's effect on intestinal anastomotic healing under physiological conditions and following preoperative whole-body irradiation. MATERIAL AND

methodsForty-five male Wistar rats received an ileoileal end-to-end anastomosis. Group 1 (Co, n = 9) served as control. Group 2 (SOM, n = 10) received pasireotide (60 mg/kg) 6 days preoperatively. Group 3 (R-Co, n = 13) was subjected to 8 Gy whole-body irradiation 4 days preoperatively. Finally, group 4 (R-SOM, n = 13) received pasireotide 6 days preoperatively and whole-body irradiation 4 days preoperatively. On postoperative day 4, anastomotic bursting pressure, histology, IGF-1 staining, and collagen density were examined.

resultsMortality was higher in irradiated animals (30.8% vs. 5.3%, p = 0.021), and anastomotic bursting pressure was significantly lower (median, R-Co = 83 mmHg; R-SOM = 101 mmHg; Co = 149.5 mmHg; SOM = 169 mmHg). Inflammation measured by leukocyte infiltration following irradiation was reduced (p = 0.023), and less collagen was observed, though this was not statistically significant. Bursting pressure did not significantly differ between Co and SOM and between R-Co and R-SOM animals respectively. Semi-quantitative scoring of IGF-1, fibroblast bridging, or collagen density did not reveal significant differences among the groups.

conclusionWhole-body irradiation decreases the quality of intestinal anastomotic wound healing and increases mortality. Pasireotide does not significantly lessen this detrimental effect.

Indexed as

Whole-Body IrradiationAnastomosis, SurgicalAnimalsBlood GlucoseBody WeightCause of DeathDisease Models, AnimalGranulocytesInjectionsInsulin-Like Growth Factor IIntestinesMalePostoperative ComplicationsPressureRats, WistarSomatostatinBlood GlucoseInsulin-Like Growth Factor IpasireotideSomatostatinAnastomosisIntestinal healingIrradiationPasireotideSOM230

Identifiers

PMID30483864
PMCPMC6331742

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.