ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2019
Multiple vitamin deficiencies additively increase the risk of incident fractures in Japanese postmenopausal women.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 25 citations in OpenAlex.
- Effect of vitamin B1 supplementation on bone turnover markers in adults: an exploratory single-arm pilot study.Journal of nutritional science · 2025Trial
- Micronutrient status among women in the midlife in selected Asian regions: a scoping review.Frontiers in global women's health · 2026Review
- Evaluating the influence of vitamin K supplementation on bone markers in hemodialysis patients.Annals of medicine and surgery (2012) · 2025Article
- Characterization of fermented foods: bone health.Frontiers in nutrition · 2025Review
- Vitamin D insufficiency and disease risk in the elderly.Journal of clinical biochemistry and nutrition · 2024Article
- PIVKA‑II is associated with liver function, bone metabolism, and muscle function in patients with liver disease.Biomedical reports · 2024Article
- Endocrine modulation of brain-skeleton axis driven by neural stem cell-derived perilipin 5 in the lipid metabolism homeostasis for bone regeneration.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Distinct dietary risk factors for incident osteoporotic fractures in early and late postmenopausal phase women.Journal of bone and mineral metabolism · 2023Article
- Article
- Stand-up test predicts occurrence of non-traumatic vertebral fracture in outpatient women with osteoporosis.Journal of bone and mineral metabolism · 2021Article
- Pentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers.Scientific reports · 2020Article
- Vitamin K Nutrition and Bone Health.Nutrients · 2020Review
- The association of urinary pentosidine levels with the prevalence of osteoporotic fractures in postmenopausal women.Journal of bone and mineral metabolism · 2019Article
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4 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The associations of multiple vitamin deficiencies on incident fractures were uncertain, the relationships between serum vitamin markers and incident bone fractures were investigated in Japanese postmenopausal women. The number of deficiencies was additively associated with incident fracture after adjustment for possible confounding factors including the treatment of osteoporosis.
introductionTo evaluate the associations of multiple vitamin deficiencies on incident fractures, the relationships between serum vitamin markers and incident bone fractures were investigated in Japanese postmenopausal women.
methodsThis analysis used a subset of the ongoing cohort maintained by a primary care institution. Inclusion criteria of the present study were postmenopausal women aged ≥ 50 years, without vitamin supplementation and secondary osteoporosis. Baseline serum concentrations of 25-hydroxyvitamin D (25(OH)D), undercarboxylated osteocalcin (ucOC), and homocysteine (Hcy) were measured to assess vitamin D, vitamin K, and vitamin B, respectively. Since 25(OH) D positively relates to vitamin D, ucOC and Hcy negatively relate to vitamin K and vitamin B nutrients, respectively, the subjects with lower (25(OH)D) or higher (ucOC or Hcy) values than each median value was defined as subjects with the corresponding vitamin deficiency. Subjects were divided into four groups according to the number of deficiency: no deficiency, single deficiency, double deficiencies, and triple deficiencies. Relationships between the vitamin deficiencies and incident fractures were evaluated by Cox regression analysis.
resultsA total of 889 subjects were included in this analysis; their mean and SD age was 68.3 ± 9.5 years, and the follow-up period was 6.3 ± 5.1 years. The numbers of subjects in the four groups were 139 (15.6%), 304 (34.2%), 316 (35.5%), and 130 (14.6%) for the groups with no, single, double, and triple deficiencies, respectively. Incident fractures were observed in 264 subjects (29.7%) during the observation period. The number of deficiencies was significantly associated with incident fracture (hazard ratio 1.25, 95% confidence interval 1.04-1.50, P = 0.018) after adjustment for possible confounding factors including the treatment of osteoporosis.
conclusionAccumulation of vitamin deficiencies was related to incident fractures.
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