ArticleJGH open : an open access journal of gastroenterology and hepatology2018
Value of routine duodenal mucosal biopsies in the evaluation of anemia in a large Australian referral centre.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 2 citations in OpenAlex.
- Assessment of the Predictive Factors Influencing the Diagnosis and Severity of Villous Atrophy in Patients with Celiac Disease and Iron Deficiency Anemia Referred for Diagnostic Endoscopy in Basrah, Iraq.Medical journal of the Islamic Republic of Iran · 2022Article
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3 authors at 1 institution in 1 country.
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Abstract
BACKGROUND AND
aimSmall bowel mucosal biopsies (SBBx) are routinely performed to investigate unexplained anemia; however, previous studies have demonstrated a low yield in diagnosing celiac disease. Our aim was to determine the yield of routine SBBx in a large cohort of patients who underwent gastroscopy for the investigation of anemia.
methodsData from consecutive patients who underwent gastroscopy for the investigation of anemia in a tertiary hospital, from January 2008-December 2011, were prospectively collected. Measured outcomes were the prevalence of celiac disease, the yield of duodenal biopsies, and the correlation between celiac serology and diagnosis.
resultsOver 4 years, 987 patients (385 M:602 F; 48.27 ± 15.89 years) underwent endoscopy for anemia, of which 534 (54.1%) had proven iron deficiency anemia (IDA). Abnormal SBBx consistent with celiac disease were found in 2% (22/987), with a higher prevalence in females (3.2%,
conclusionOnly 2% of patients with unexplained anemia had abnormal SBBx consistent with celiac disease and even fewer patients in non-IDA. Given the availability and high sensitivity of celiac serology and macroscopic changes on endoscopy, SBBx should not be routine during endoscopy but should be limited to those with positive celiac serology, abnormal endoscopic appearance, or females with IDA.
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