ArticleJGH open : an open access journal of gastroenterology and hepatology2018
Quality of life in celiac disease and the effect of gluten-free diet.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04351828 (The Investigation of Nutritional Status, Intestinal Permeability and Quality of Life in People With Celiac Disease), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Investigation of Nutritional Status, Intestinal Permeability and Quality of Life in People With Celiac Disease
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Pooled it
- Beyond the Gut: Brain Fog, Sleep Quality, Cognitive Function and Quality of Life in Celiac Disease.Nutrients · 2026Observational
- Review
- Validity and Reliability of the Turkish Version of the Celiac Dietary Adherence Test.Medicina (Kaunas, Lithuania) · 2025Article
- Gluten-free diet adherence patterns and health outcomes in celiac disease: a retrospective observational study.BMC gastroenterology · 2025Observational
- Comparison of Quality of Life, Anxiety, and Depression Levels in Celiac Patients With Children Without Chronic Illnesses.Children (Basel, Switzerland) · 2025Article
- Evaluation of Quality of Life in Adult Celiac Patients Living in Lithuania and Their Compliance with a Gluten-Free Diet: A Pilot Study.Medicina (Kaunas, Lithuania) · 2025Article
- Gluten-Free Diet and Health-Related Quality of Life: The Validated Hellenic Version of the Celiac Dietary Adherence Test.Nutrients · 2025Article
- Article
- Article
- Article
- Health-related quality of life among celiacs in Portugal: a comparison between general and specific questionnaires.Frontiers in immunology · 2024Article
- Quality of Life Perception among Portuguese Celiac Patients: A Cross-Sectional Study Using the Celiac Disease Questionnaire (CDQ).Nutrients · 2023Article
- The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022Article
- Impact of delay in diagnosis in patients with celiac disease: A study of 570 patients at a tertiary care center.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2022Article
- Health related QoL in celiac disease patients in Slovenia.Health and quality of life outcomes · 2020Article
- Article
- Health-related quality of life using specific and generic questionnaires in Spanish coeliac children.Health and quality of life outcomes · 2020Article
- Twitter Trends for Celiac Disease and the Gluten-Free Diet: Cross-sectional Descriptive Analysis.JMIR infodemiologyArticle
- [Empowerment and Quality of Life in Adults with Celiac Disease. A Cross-Sectional Study].Acta gastroenterologica LatinoamericanaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimPatients with celiac disease (CD) have a poor health-related quality of life (HR-QOL). We assessed the QOL in patients with CD using both generic (SF-12) and specific (CD-QOL) questionnaires, and the effect of gluten-free diet (GFD) on HR-QOL.
methodsWe conducted a prospective follow-up study based on consecutive patients of suspected CD between June 2014 and November 2015. After taking a detailed history, all patients were subjected to laboratory investigations (including complete blood count, biochemistry, and the IgA tTG antibody), followed by endoscopy and duodenal biopsies for histopathology. The HR-QOL was assessed using SF-12 and CD-QOL questionnaires. Patients who were strictly adherent to GFD were re-assessed at the end of 6 months for laboratory parameters and QOL.
resultsSixty adult patients of CD, with mean age of 28.85 ± 12.43 years, and a M:F ratio of 1.3:1, were enrolled in the study. The mean PCS (physical health composite scale score) and MCS (mental health composite scale score) at baseline were 37.20 ± 11.09 and 41.88 ± 8.39, which showed a statistically significant improvement after GFD to 50.30 ± 9.88 and 50.22 ± 9.04, respectively. Though there was no significant difference in the total CD-QOL score after GFD, there was a significant improvement in the dysphoria and health-concern subscales. We also found a negative correlation of the pre-GFD symptom score (based on number of positive symptoms) with PCS and MCS and a positive correlation with the CD-QOL score.
conclusionThis study has shown a reduced HR-QOL in adult CD patients, which improves significantly on GFD, and is associated with a higher symptom number.
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